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Professor Immacolata Castellano, Professor Of Biochemistry And Expert In Marine Natural Products And Oxidative Stress.

Italy

Professor Of Biochemistry, Department Of Molecular Medicine And Medical Biotechnology

ORCID: 0000-0002-4274-6738

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Professor Immacolata Castellano

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University Of Naples Federico II, Naples, Italy


Academic Metrics
  • h-Index: 30
  • i10-Index: 48
  • Total Citations: 2181

Research Interests:

Professor Castellano's core focus is on the molecular and cellular foundations of life and adaptation:

  • Biochemistry And Molecular Biology
  • Marine Biochemistry And Natural Products
  • Antioxidant Enzymes And Redox Homeostasis
  • Oxidative Stress And Signal Transduction
  • Structure, Function, And Protein Evolution

Biography:

Professor Immacolata Castellano is a distinguished Professor of Biochemistry specializing in Marine Biochemistry and Oxidative Stress. Her research focuses on the molecular mechanisms regulating biological processes in marine organisms and their adaptation to environmental factors. She studies the structure, function, and evolution of antioxidant enzymes and redox-sensitive signal transduction pathways. Recently, her work has focused on characterizing the therapeutic potential and biological activities of sulfur-containing natural products derived from marine life.


Education Details

Professor Castellano's extensive academic background is centered in biochemistry and molecular biology in Italy:

  • PhD (Biochemistry And Cellular And Molecular Biology): University Federico II, Naples, Italy (2007).
  • Master Degree (Biological Sciences): University Federico II, Naples, Italy (2001).
     
Professional Background

Her career has involved research at Italy's leading scientific institutions, culminating in her current professorship:

  • Professor Of Biochemistry (BIO/10) (Current, Since 2020) - University Of Naples Federico II.
  • Associate Researcher (Current, Since 2020) - Stazione Zoologica Anton Dohrn, Naples.
  • Researcher (Permanent Position) (2018–2020) - Stazione Zoologica Anton Dohrn.
  • Post-doc Research Fellow (2007–2010) - Institute Of Protein Biochemistry, National Research Council, Naples.


Achievements

Professor Castellano has been recognized for her research in marine and molecular biochemistry:

  • First “Aldo Fasolo” Prize for young researchers (2014).
  • Member of the Italian Society Of Biochemistry And Molecular Biology (SIB) since 2008.

Current Research Projects

Her current research is focused on translating marine biochemical discoveries to human health applications:

  • Antioxidant Enzymes: Studying the evolution of novel biological functions, with emphasis on antioxidant enzymes and their redox homeostasis.
  • Marine Natural Products: Characterizing the biological properties and therapeutic potential of sulfur-containing natural products derived from marine organisms.

Academic Profiles Of Professor Immacolata Castellano

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Publications:

Professor Castellano's recent publications are highly current, detailing new discoveries on molecular evolution, novel antioxidant compounds, and their potential for human health applications.

The list of recent publications of Professor Immacolata Castellano is listed below:
 

  1. Zuccarotto, A., Russo, M., Di Giacomo, A., Casale, A., Mitrić, A., Leone, S., Russo, G. L., & Castellano, I. (2025). Marine-Inspired Ovothiol Analogs Inhibit Membrane-Bound Gamma-Glutamyl-Transpeptidase and Modulate Reactive Oxygen Species and Glutathione Levels in Human Leukemic Cells. Marine Drugs, 23(8), 308.
  2. Zuccarotto, A., Sollitto, M., Leclère, L., Panzella, L., Gerdol, M., Leone, S., & Castellano, I. (2025). Molecular evolution of ovothiol biosynthesis in animal life reveals diversity of the natural antioxidant ovothiols in Cnidaria. Free Radical Biology And Medicine, 227, 117-128.
  3. Luccarini, A., Marcheggiani, F., Galeazzi, R., Zuccarotto, A., Castellano, I., & Damiani, E. (2025). Characterizing the Ultraviolet (UV) Screening Ability of L-5-Sulfanylhistidine Derivatives on Human Dermal Fibroblasts. International Journal Of Molecular Sciences, 26(3), 2561.
  4. Luccarini, A., Zuccarotto, A., Galeazzi, R., Morresi, C., Masullo, M., Castellano, I., & Damiani, E. (2024). Insights on the UV-Screening Potential of Marine-Inspired Thiol Compounds. Marine Drugs, 22(1), 2.
  5. Russo, M. T., Santin, A., Zuccarotto, A., Leone, S., Palumbo, A., Ferrante, M. I., & Castellano, I. (2023). The first genetic engineered system for ovothiol biosynthesis in diatoms reveals a mitochondrial localization for the sulfoxide synthase OvoA. Open Biology, 13(10), 220309.
     

Last Updated on September 30, 2025