About Journal of Colon and Rectal Cancer
Advancing molecular understanding of colorectal cancer through rigorous, peer-reviewed research focused on disease mechanisms, biomarkers, and pathophysiology
Mechanistic Focus
Publishing research that elucidates cellular pathways, genetic alterations, and molecular mechanisms driving colorectal cancer initiation, progression, and metastasis.
Biomarker Discovery
Advancing identification and validation of diagnostic, prognostic, and predictive biomarkers through genomic, proteomic, and metabolomic investigations.
Translational Bridge
Connecting laboratory discoveries to potential clinical applications by highlighting mechanistic insights that inform therapeutic target development.
JCRC welcomes original research articles, comprehensive reviews, and methodological papers that advance our molecular understanding of colorectal cancer. Our scope encompasses diverse aspects of disease pathophysiology while maintaining strict focus on mechanisms rather than clinical practice.
Oncogene activation, tumor suppressor inactivation, microsatellite instability, chromosomal instability, DNA methylation patterns, and chromatin remodeling mechanisms.
Wnt/?-catenin, MAPK/ERK, PI3K/AKT, TGF-?, Notch, and Hedgehog pathway alterations in colorectal tumorigenesis and progression.
Cancer-associated fibroblasts, immune cell infiltration, extracellular matrix remodeling, hypoxia signaling, and metabolic reprogramming within the tumor ecosystem.
Discovery and validation of circulating tumor DNA, protein markers, metabolic signatures, exosomal cargo, and multi-omics panels for disease detection and monitoring.
Epithelial-mesenchymal transition, invasion biology, angiogenesis, lymphangiogenesis, organ-specific metastatic tropism, and pre-metastatic niche formation.
Identification, characterization, and functional analysis of colorectal cancer stem cell populations, self-renewal mechanisms, and differentiation pathways.
Consensus molecular subtyping, transcriptomic classification systems, proteomic profiling, and integrative multi-platform characterization approaches.
Development and validation of cell lines, organoid systems, patient-derived xenografts, genetically engineered mouse models, and in vitro/in vivo platforms.
Histopathological correlates of molecular alterations, spatial omics, tissue-based biomarker analysis, and pathophysiological classification systems.
JCRC publishes diverse article types to accommodate the breadth of colorectal cancer research while maintaining rigorous standards for mechanistic insight and scientific rigor.
- Original Research Articles: Comprehensive reports of novel mechanistic findings, biomarker discovery studies, or methodological advances in colorectal cancer research
- Systematic Reviews & Meta-Analyses: Systematic evidence synthesis and meta-analyses focused on molecular mechanisms or biomarker performance
- Review Articles & Literature Reviews & Mini-Reviews: Narrative and comprehensive reviews synthesizing current understanding of specific molecular mechanisms, pathways, or biomarker landscapes
- Methods & Resources & Methodology Articles: Detailed descriptions of innovative experimental approaches, analytical techniques, or model systems for studying colorectal cancer biology
- Mechanistic Studies: Research emphasizing cellular and molecular pathways, disease processes, and functional mechanisms in colorectal cancer
- Short Communications & Rapid Communications: Rapid dissemination of significant preliminary findings, novel observations, or technical innovations
- Technical Notes: Concise reports on novel techniques, modifications to existing methods, or technical insights
- Data Reports & Data Notes: Comprehensive datasets from genomic, transcriptomic, proteomic, or metabolomic studies with detailed annotation
- Perspectives & Commentaries: Expert viewpoints on emerging trends, controversies, or future directions in colorectal cancer research
- Opinion Pieces: Author-driven perspectives on scientific, ethical, or policy issues in molecular oncology
- Case Reports & Case Series: Detailed descriptions of rare molecular phenotypes or exceptional mechanistic insights from clinical cases
- Clinical Trials: Reports of mechanistic endpoints, biomarker analyses, or molecular profiling from interventional studies
- Letters to Editor: Scholarly correspondence addressing previously published articles or presenting timely scientific observations
- Editorials: Invited articles from editorial board members on key topics or special issues
- Conference Proceedings: Selected papers from scientific meetings focused on colorectal cancer mechanisms
- Book Reviews: Critical evaluations of recent publications in cancer biology and molecular oncology
- Theses & Dissertation-Based Submissions: Condensed versions of doctoral research contributing novel mechanistic insights
Rigorous Single-Blind Review: Every submission undergoes evaluation by at least two independent experts in molecular oncology, cancer biology, or relevant specialized fields. Reviewers assess mechanistic rigor, experimental design, analytical validity, reproducibility, and significance of findings. Authors receive constructive feedback regardless of publication decision. The average time to first decision is 21 days.
Initial Screening
Editorial team evaluates scope alignment, focusing on mechanistic content rather than clinical application. Manuscripts emphasizing patient management or therapeutic protocols are redirected to appropriate clinical journals. Initial screening completed within 3 business days.
Expert Review Assignment
Manuscripts are assigned to reviewers with expertise in relevant molecular pathways, experimental systems, or analytical methodologies. Reviewers assess mechanistic insights, methodological rigor, and reproducibility. Review process targets completion within 21 days.
Author Revision
Authors receive detailed feedback addressing experimental design, data interpretation, mechanistic conclusions, and presentation clarity. Point-by-point responses to reviewer comments are required. Revised manuscripts are typically reassessed within 7–10 days.
Final Decision and Publication
Revised manuscripts undergo final editorial evaluation. Accepted articles are professionally copyedited, proofread, and published online with immediate open-access availability. The average time from acceptance to publication is 3 days.
Authors submitting to JCRC should carefully review our Instructions for Authors to ensure manuscripts align with our mechanistic focus. Key requirements include:
Clear articulation of molecular mechanisms, cellular pathways, or disease processes investigated
Detailed methods, appropriate controls, statistical analysis, and reproducibility considerations
Raw data availability, reagent specifications, and adherence to reporting guidelines (ARRIVE, MIQE, etc.)
Institutional approval for human biospecimen studies, IACUC protocols for animal research, conflict of interest disclosure
Scope Clarity: JCRC focuses exclusively on disease mechanisms and molecular pathophysiology. Manuscripts primarily addressing clinical outcomes, therapeutic efficacy, patient management protocols, or healthcare delivery fall outside our scope. Authors should emphasize mechanistic insights, biomarker discovery, or fundamental disease biology rather than clinical applications.
Expert Editorial Oversight
JCRC's editorial operations are guided by an international Editorial Board comprising distinguished researchers in molecular oncology, cancer genetics, tumor biology, and translational research. Board members provide strategic direction, evaluate manuscripts in their areas of expertise, and ensure published research meets the highest standards of scientific rigor.
Our editors bring diverse methodological expertise spanning genomics, proteomics, systems biology, animal models, organoid technology, and computational approaches, ensuring comprehensive evaluation of mechanistic research across all colorectal cancer biology domains.
JCRC operates as a fully open-access journal, removing barriers to knowledge dissemination and maximizing research impact. Published articles are immediately available worldwide without subscription fees, enabling researchers in resource-limited settings to access cutting-edge molecular cancer research.
Copyright and Licensing: Authors retain copyright under Creative Commons Attribution 4.0 International (CC BY 4.0) license, permitting unrestricted use, distribution, and reproduction with appropriate attribution. This facilitates knowledge translation, educational use, and integration into systematic reviews and meta-analyses.
JCRC content is indexed in major bibliographic databases and discovery services, ensuring maximum visibility within the research community. Our articles are discoverable through Google Scholar, ResearchGate, academic institutional repositories, and specialized oncology research platforms.
Contribute to Colorectal Cancer Research
Join our global community of researchers advancing molecular understanding of colorectal cancer. Submit your mechanistic discoveries, biomarker studies, and translational research to JCRC and benefit from rigorous peer review, rapid publication, and open-access dissemination. With an acceptance rate of 53% and average submission-to-publication time of 30 days, JCRC offers an efficient path to scholarly impact.
Contact Information: For inquiries about manuscript suitability, editorial policies, or submission procedures, contact the JCRC editorial office at [email protected]. Our team is committed to providing responsive, professional support throughout the publication process.
