Aims & Scope
Core Research Domains
Molecular Networks & Interactions
- Gene regulatory networks and transcriptional control
- Protein-protein interaction networks
- Metabolic pathway analysis and flux modeling
- Signal transduction cascades and cellular signaling
- Post-translational modification networks
- RNA regulatory networks and non-coding RNA function
Computational & Quantitative Biology
- Mathematical modeling of biological systems
- Network topology analysis and graph theory applications
- Systems dynamics and differential equation modeling
- Stochastic modeling of molecular processes
- Algorithm development for biological data analysis
- Machine learning applications in omics data integration
Omics Technologies & Integration
- Genomics and functional genomics approaches
- Transcriptomics and gene expression profiling
- Proteomics and protein expression analysis
- Metabolomics and metabolic profiling
- Epigenomics and chromatin state analysis
- Multi-omics data integration and systems-level interpretation
Structural & Molecular Biology
- Protein structure-function relationships
- Molecular dynamics simulations
- Structural biology and macromolecular assemblies
- Computational chemistry and molecular modeling
- Biophysical chemistry of biomolecular interactions
- DNA-protein interactions and genome architecture
Secondary Focus Areas
Synthetic Biology & Bioengineering
Design and construction of artificial biological systems, genetic circuits, and engineered molecular networks for understanding fundamental biological principles.
Evolutionary Systems Biology
Network evolution, adaptive dynamics, molecular evolution of regulatory systems, and phylogenetic analysis of biological networks.
Bioinformatics Tools & Databases
Development of computational tools, databases, and software platforms for systems-level analysis of biological data and network visualization.
Microbial Systems Biology
Systems-level analysis of microbial metabolism, gene regulation, and cellular networks in bacteria, archaea, and fungi.
Ecological Network Modeling
Mathematical modeling of ecological interactions, population dynamics, and ecosystem-level network analysis with molecular underpinnings.
Biotechnology Applications
Systems biology approaches to metabolic engineering, biosensor development, and optimization of biological production systems.
Emerging Research Frontiers
Selective Consideration
Explicitly Out of Scope
We Do Not Consider
Clinical Medicine & Patient Care
Clinical trials, patient outcomes, treatment efficacy studies, clinical diagnostics, or medical device performance without fundamental molecular mechanisms.
Applied Medical Imaging
Medical imaging techniques, diagnostic imaging, or clinical radiology studies unless directly coupled with molecular-level systems analysis.
Engineering Systems (Non-Biological)
Power systems engineering, robotics research, or general data engineering without direct biological systems application.
Pure Medicinal Chemistry
Drug synthesis, pharmaceutical formulation, or medicinal chemistry without systems-level biological network analysis.
Descriptive Clinical Studies
Observational clinical studies, epidemiological surveys, or health outcomes research without molecular systems insights.
Article Types & Priorities
Fast-Track Review
Standard Review
By Invitation Only
Editorial Standards & Requirements
Reporting Guidelines
- ARRIVE for animal studies
- MIAME for microarray data
- MIQE for qPCR experiments
- STROBE for observational studies
- PRISMA for systematic reviews
Data Availability
- Raw data deposition in public repositories
- Code and algorithms shared via GitHub/Zenodo
- Proteomics data in PRIDE/ProteomeXchange
- Genomics data in GEO/ArrayExpress/SRA
- Metabolomics data in MetaboLights
Ethics & Compliance
- IRB/Ethics committee approval for human samples
- IACUC approval for animal research
- Informed consent documentation
- Biosafety and biosecurity compliance
- Conflict of interest disclosure
Preprint Policy
- Preprints on bioRxiv/arXiv accepted
- Must be disclosed during submission
- No impact on editorial consideration
- Version control maintained
- DOI linking to final publication
Decision Metrics
Ready to Submit?
If your research focuses on molecular mechanisms, computational modeling, or systems-level understanding of biological networks, we invite you to submit your manuscript.
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