Research Topic · Peer-Reviewed

Chronic Fatigue Syndrome

Chronic fatigue syndrome (CFS), also termed myalgic encephalomyelitis (ME) and systemic exertion intolerance disease (SEID), is a complex, debilitating condition defined by profound, persistent fatigue lasting at least six months that is not relieved by rest and is accompanied by post-exertional malaise, unrefreshin…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 13× across the literature 🔖 ISSN 2381-862X 🗓 Reviewed October 2026

Overview

Chronic fatigue syndrome (CFS), also termed myalgic encephalomyelitis (ME) and systemic exertion intolerance disease (SEID), is a complex, debilitating condition defined by profound, persistent fatigue lasting at least six months that is not relieved by rest and is accompanied by post-exertional malaise, unrefreshing sleep, cognitive impairment, and often pain. Its etiology remains incompletely understood and is thought to involve interacting immunological, neuroendocrine, autonomic, and infectious factors, with symptom overlap across multiple body systems complicating diagnosis, which rests on clinical criteria and exclusion of alternative causes. Research relevant to the condition examines chronic stress and its biological correlates, oxidative and inflammatory mechanisms, chronic pain and pain-related cytokine modulation through interventions such as auricular vagus nerve stimulation, and infectious contributors including tick-borne illness. The interplay of fatigue with mood, sleep, and immune dysregulation situates CFS within a broader landscape of chronic, multisystem illness in which energy metabolism, neuroimmune signaling, and stress physiology are central. Because the condition affects daily functioning and quality of life across affected populations, management is typically supportive and multidisciplinary. The journal publishes peer-reviewed clinical and mechanistic studies and reviews addressing chronic fatigue, chronic pain, stress physiology, and the immunological and neuroendocrine factors implicated in persistent, multisystem fatigue.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 13 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Chronic Fatigue Syndrome, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Women's Reproductive Health (ISSN 2381-862X).

Journal editorial board
Qiuqin Tang · China Akmal El-Mazny · Egypt Anup Pradhan · India

This page summarises published research for orientation; it is not medical or professional advice.