Research Topic · Peer-Reviewed

Cluster Headache

Cluster headache is a rare neurological condition characterized by a recurrent, unilateral, episodic and excruciatingly painful headache. It is the most severe type of headache and the most common of the trigeminal autonomic cephalalgias. Despite its rarity, it is a major cause of disability and has a strong impact …

📚 0 peer-reviewed articles cited 🗓 Reviewed June 2026

Overview

Cluster headache is a rare neurological condition characterized by a recurrent, unilateral, episodic and excruciatingly painful headache. It is the most severe type of headache and the most common of the trigeminal autonomic cephalalgias. Despite its rarity, it is a major cause of disability and has a strong impact on patients’ quality of life. It is believed to be caused by abnormal activation of pain-sensory pathways in the brain, and is treated with drugs such as steroids, triptans and even oxygen therapy. As an additional treatment option, nerve stimulation, acupuncture and psychotherapy may be used to provide relief to those suffering from this debilitating condition. Cluster headache has been gaining recognition in recent years as a serious medical disorder that requires prompt and effective intervention.

Research published in this journal

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Editorial oversight

Curated from peer-reviewed research published in Migraine Management.

Journal editorial board
Jing Xiang · United States Frederick Freitag · United States Yohannes W. Woldeamanuel · United States

This page summarises published research for orientation; it is not medical or professional advice.