Research Topic · Peer-Reviewed

Atherosclerosis

Atherosclerosis is a chronic, progressive disease of the arterial wall characterised by the accumulation of lipid, inflammatory cells, smooth-muscle cells, and fibrous tissue into plaques that thicken and stiffen the intima and narrow the lumen. Its pathogenesis begins with endothelial dysfunction and the retention …

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 55× across the literature 🗓 Reviewed July 2026

Overview

Atherosclerosis is a chronic, progressive disease of the arterial wall characterised by the accumulation of lipid, inflammatory cells, smooth-muscle cells, and fibrous tissue into plaques that thicken and stiffen the intima and narrow the lumen. Its pathogenesis begins with endothelial dysfunction and the retention and oxidation of low-density lipoprotein, followed by monocyte recruitment, foam-cell formation, and an inflammatory cascade that drives plaque growth; advanced lesions may rupture and trigger thrombosis. Atherosclerosis is the principal substrate of coronary artery disease, ischaemic stroke, and peripheral arterial disease, and contributes to aneurysm formation. Recognised risk factors include dyslipidaemia, hypertension, diabetes, oxidative stress, and lifestyle exposures, while subclinical disease is assessed through markers such as carotid intima-media thickness and coronary artery calcification. Research spans the molecular and genetic determinants of susceptibility, including coronary-disease-associated polymorphisms and microRNA regulation, endothelial function, lipid metabolism, and the interplay with metabolic and inflammatory conditions. The International Journal of Multiple Sclerosis and Related Disorders, alongside the publisher's cardiology and related titles, carries peer-reviewed research engaging these themes, including atherosclerosis risk-factor analysis, bioinformatic study of coronary-disease genes, endothelial function in stroke subtypes, carotid intima-media thickness, and microRNA in vascular disease, grounding the topic in vascular pathology relevant to cerebrovascular and neurological outcomes.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Endothelial Function in Stroke Subtypes Using Endopat Technology

Enrique Jiménez Caballero PedroCorresponding author
Department of Neurology, San Pedro de Alcántara Hospital, Avenida de Pablo Naranjo nº 2, 10003. Cáceres. Spain.
Exact topic Neurological Research and Therapy Cited by 4 doi:10.14302/issn.2470-5020.jnrt-14-558

How this research is being cited

The 12 articles above have been cited 55 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Atherosclerosis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Multiple Sclerosis and Related Disorders.

Journal editorial board
Jorge Matias-Guiu · Spain Anne Vejux · France

This page summarises published research for orientation; it is not medical or professional advice.