Congenital heart disease comprises structural abnormalities of the heart and great vessels present at birth, arising from disordered cardiac development during embryogenesis. It is the most common category of birth defect and ranges from minor lesions to complex, life-threatening malformations, including septal defe…
Congenital heart disease comprises structural abnormalities of the heart and great vessels present at birth, arising from disordered cardiac development during embryogenesis. It is the most common category of birth defect and ranges from minor lesions to complex, life-threatening malformations, including septal defects, valvular and outflow-tract anomalies, single-ventricle physiology and abnormalities of the great arteries. These defects alter normal blood flow, may cause cyanosis, heart failure, impaired growth and exercise limitation, and can require catheter-based or surgical intervention. Aetiology is multifactorial, involving genetic, chromosomal and environmental influences, and presentation may occur prenatally, in the neonatal period or later in life, with survivors increasingly reaching adulthood and requiring ongoing cardiovascular care. Diagnosis relies on clinical assessment, echocardiography and prenatal and cross-sectional imaging. Research collected under this term reflects these dimensions: prevalence of congenital heart defects among neonates, cardiovascular risk-factor trajectories in congenital heart disease, Ebstein's anomaly with atrial thrombus, fetal surgery, syndromic associations such as Ellis–van Creveld, prenatal diagnosis of left isomerism, heart failure in primary care, vital-organ biomarker studies, in vitro cardiac-function assessment, and nutritional status in single-ventricle physiology. The peer-reviewed literature in this area spans the structural spectrum, prenatal and postnatal diagnosis, and the clinical management and outcomes of congenital cardiac malformations across the lifespan.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 32 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Congenital Heart, linking to each citing work.