Research Topic · Peer-Reviewed

Hedgehog Signaling

Hedgehog (Hh) signaling is a cellular pathway that is essential for development and tissue homeostasis. This pathway, first discovered in the fruit fly, is so named because it was originally discovered to be involved in the formation of spines on the animal's body, known as “hedgehogs”. In humans and other animals, …

Curated from this journal's research 📚 3 peer-reviewed articles cited Cited 3× across the literature 🗓 Reviewed June 2026

Overview

Hedgehog (Hh) signaling is a cellular pathway that is essential for development and tissue homeostasis. This pathway, first discovered in the fruit fly, is so named because it was originally discovered to be involved in the formation of spines on the animal's body, known as “hedgehogs”. In humans and other animals, the Hh signaling pathway is also essential for proper development, playing a role in the formation of a variety of organs and tissues, including skeletal muscles, skin, intestines and the nervous system. If there is a malfunction in this pathway, it can cause genetic disorders and cancers. The Hh signaling pathway is a major research focus in the field of oncology, as it is believed that understanding how it works can lead to new drugs that target cancers associated with the pathway.

Research published in this journal

3 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 3 articles above have been cited 3 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Hedgehog Signaling, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Cell.

Journal editorial board
Faiz Ul Amin · Korea, Democratic People's Rep Yuping Li · United States Hong WAN · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.