Antibodies, also called immunoglobulins, are glycoproteins generated by B lymphocytes and plasma cells that bind antigens with high specificity, enabling the immune system to recognize and eliminate bacteria, viruses, and other threats. The basic molecule consists of paired heavy and light chains forming two antigen…
Antibodies, also called immunoglobulins, are glycoproteins generated by B lymphocytes and plasma cells that bind antigens with high specificity, enabling the immune system to recognize and eliminate bacteria, viruses, and other threats. The basic molecule consists of paired heavy and light chains forming two antigen-binding arms, whose variable complementarity-determining regions dictate specificity, and a constant region that recruits effector mechanisms such as complement activation, phagocyte engagement, and signaling through Fc receptors. The isotypes IgG, IgM, IgA, IgE, and IgD differ in their structural and functional properties. Antibodies neutralize pathogens and toxins—exemplified by neutralizing antibodies in convalescent immune plasma against SARS-CoV-2—and constitute the protective output of vaccination. Engineered derivatives, including monoclonal antibodies, single-chain variable fragments, and single-domain antibodies, serve as therapeutics and diagnostic reagents, while autoantibodies are implicated in autoimmune and hematologic conditions. Antibody-based immunoassays such as ELISA are mainstays of diagnosis and of immunomonitoring in cancer and infectious disease. The research reflected here includes neutralizing antibodies in immune plasma, single-domain and monoclonal antibody generation, donor-specific anti-HLA antibodies in transplantation, autoantibodies in hematological malignancy, and immunoassay and immunogenomic approaches. The journal publishes peer-reviewed studies on antibody structure and function, antibody engineering, and immunodiagnostic applications.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 29 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Antibodies, linking to each citing work.