Research Topic · Peer-Reviewed

Ornithine

transcarbamylase Ornithine transcarbamylase (OTC) is an enzyme that catalyzes the conversion of carbon skeleton from one molecule to another. This enzyme is important for the proper function of the urea cycle, a cellular process that helps organisms to break down nitrogen-containing compounds such as ammonia. OTC d…

Curated from this journal's research 📚 2 peer-reviewed articles cited Cited 9× across the literature 🗓 Reviewed June 2026

Overview

transcarbamylase Ornithine transcarbamylase (OTC) is an enzyme that catalyzes the conversion of carbon skeleton from one molecule to another. This enzyme is important for the proper function of the urea cycle, a cellular process that helps organisms to break down nitrogen-containing compounds such as ammonia. OTC deficiency is the most common urea cycle disorder in humans and leads to a potentially life-threatening accumulation of ammonia in the blood. Diagnosis and management of OTC deficiency involves enzyme replacement therapies, dietary interventions, and medications. Because of the importance of OTC for proper functioning of the urea cycle, this enzyme can be used in research as a biomarker to study the health of the urea cycle in organisms and to identify potential new treatments for OTC deficiency.

Research published in this journal

2 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 2 articles above have been cited 9 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Ornithine, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Amino Acids.

Journal editorial board
Nicolas Inguimbert · France

This page summarises published research for orientation; it is not medical or professional advice.