The aging process, or biological ageing, is the progressive, time-dependent decline in physiological integrity and function accompanied by an increasing vulnerability to disease and death. It is understood through a set of interrelated molecular and cellular hallmarks, including telomere attrition and altered telome…
The aging process, or biological ageing, is the progressive, time-dependent decline in physiological integrity and function accompanied by an increasing vulnerability to disease and death. It is understood through a set of interrelated molecular and cellular hallmarks, including telomere attrition and altered telomerase activity, cellular senescence, genomic instability and accumulated DNA damage, mitochondrial dysfunction with oxidative stress, and dysregulated nutrient sensing in which sirtuins such as SIRT1 act as key longevity-associated regulators. These mechanisms are dissected experimentally using model systems, including D-galactose-induced accelerated-aging models and long-lived dwarf-mouse models, and through kinetic and systems-level modeling of living organisms. Interventions are studied for their capacity to extend healthspan rather than merely lifespan, spanning pharmacological modulators, dietary factors, melatonin, and physical activity. Peer-reviewed research in this area examines SIRT1 and telomerase-related anti-aging activity in vitro, muscle dysfunction and healthy aging in relation to melatonin, longevity in D-galactose-induced models, open-air exercise to decelerate aging, learning and memory in long-lived Ames dwarf mice, body composition in nonagenarians, and the effects of grape juice on weight and DNA damage in older adults. Together these strands link the cellular determinants of senescence to lifestyle and longevity-oriented interventions.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 34 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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