Melike Caglayan PhD (Boğaziçi University)
Associate Professor, University of Nebraska Medical Center, Omaha, Nebraska · United States
Editorial leadership for Journal of Enzymes ISSN 2690-4829
Research interests
- Oxidative Stress Genome Maintenance Dna Repair Nucleic Acids Enzymology
Biography
Dr. Melike Caglayan is an Associate Professor at the University of Nebraska Medical Center in Omaha, Nebraska, United States. She earned her PhD from Boğaziçi University, where her doctoral work focused on investigating the temperature effect on the fidelity of bacterial DNA replication and DNA polymerase transient state kinetics. In 2013, she joined the laboratory of Dr. Samuel H. Wilson at the National Institutes of Health (NIH), National Institute of Environmental Health Sciences (NIEHS), to study base excision DNA repair by characterizing nucleic acid-protein and protein-protein interactions and their role in coordinating the sequential enzymatic steps of the DNA repair pathway. Her most-cited publication, "The ligation of pol β mismatch insertion products governs the formation of promutagenic base excision DNA repair intermediates" (2020), has been cited 33 times, and she has authored 19 or more indexed publications.
Selected publications
- The ligation of pol β mismatch insertion products governs the formation of promutagenic base excision DNA repair intermediates 2020 cited 33×
- DNA ligase I variants fail in the ligation of mutagenic repair intermediates with mismatches and oxidative DNA damage 2020 cited 28×
- Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair 2022 cited 27×
- Unfilled gaps by polβ lead to aberrant ligation by LIG1 at the downstream steps of base excision repair pathway 2024 cited 13×
- Impact of DNA ligase 1 and IIIα interactions with APE1 and polβ on the efficiency of base excision repair pathway at the downstream steps 2024 cited 13×
- Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA 2024 cited 13×
Ranked by citation impact (Crossref) where available, newest otherwise · verified via ORCID.
Considering JEN for your work?
This journal is guided by Melike Caglayan (Associate Professor, University of Nebraska Medical Center, Omaha, Nebraska) and a peer-review board of practising researchers. Open access, author-retained copyright (CC BY), and a clear editorial process.