Journal of Enzymes

Melike Caglayan, Associate Professor, University of Nebraska Medical Center, Omaha, Nebraska
Editorial Board

Melike Caglayan PhD (Boğaziçi University)

Associate Professor, University of Nebraska Medical Center, Omaha, Nebraska · United States

Editorial leadership for Journal of Enzymes ISSN 2690-4829

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Research interests

  • Oxidative Stress Genome Maintenance Dna Repair Nucleic Acids Enzymology

Biography

Dr. Melike Caglayan is an Associate Professor at the University of Nebraska Medical Center in Omaha, Nebraska, United States. She earned her PhD from Boğaziçi University, where her doctoral work focused on investigating the temperature effect on the fidelity of bacterial DNA replication and DNA polymerase transient state kinetics. In 2013, she joined the laboratory of Dr. Samuel H. Wilson at the National Institutes of Health (NIH), National Institute of Environmental Health Sciences (NIEHS), to study base excision DNA repair by characterizing nucleic acid-protein and protein-protein interactions and their role in coordinating the sequential enzymatic steps of the DNA repair pathway. Her most-cited publication, "The ligation of pol β mismatch insertion products governs the formation of promutagenic base excision DNA repair intermediates" (2020), has been cited 33 times, and she has authored 19 or more indexed publications.

Selected publications

1) Caglayan M. and Wilson S.H. Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals a
promutagenic DNA intermediate during double strand break repair. Nature Communications (2018) 9:4213.
2) Horton J.K., Stefanick D.F., Caglayan M., Zhao M.L., Gassman N.R., Wilson S.H. XRCC1 phosphorylation
affects aprataxin recruitment and DNA deadenylation activity. DNA Repair (2018)– 64:26– 33.
3) Prasad R., Caglayan M., Da-Peng D.,Nadalutti C.A., Gassman N.R., Zhao M., Stefanick D.F.,Horton J.K.,
Krasich R., Longley M.J., Copeland W.C.,Griffith J.D., WilsonS.H. DNA polymerase β: The missing link of the
base excision repair machinery in mammalian mitochondria. DNA Repair (2017) 60: 77 – 88.
4) Caglayan M., Prasad R., Krasich R., Longley M.J., Kadoda K.,Tsuda M.,Sasanuma H.,Takeda S.,Tano K.,
Copeland W.C., Wilson S.H.Complementation of aprataxin deficiency by base  excision repair enzymes in
mitochondrial extracts.Nucleic Acids Research (2017) 17:10079– 10088.
5) Caglayan M., Wilson S.H.Role of DNA polymerase βoxidized nucleotide insertion in DNA ligation failure.
Journal of Radiation Research - Review article (2017)1093: 1 – 5.
6) Caglayan M., Horton J.K., Da-Peng D., Stefanick D.F., Wilson S.H. Oxidized nucleotide insertion by pol β
confounds ligation during base excision repair. Nature Communications (2017) 8: 14045.
7) Sassa A., Caglayan M.,Rodriguez Y.,Beard W.A., Wilson S.H.,Nohmi T.,Honma M.,Yasui M.Impact of
ribonucleotide backbone on translesion synthesis andrepair of 7,8-Dihydro-8-oxoguanine. Journal of
Biological Chemistry (2016) 291: 24314 – 24323.
8) Caglayan M., Wilson S.H.Oxidant and environmental toxicant-induced effects compromise DNA ligation
during base excision DNA repair. DNA Repair - Review article (2015) 35:85– 89.
9) Caglayan M., Horton J.K.,Prasad R.,Wilson S.H.Complementation of aprataxin deficiency by base excision repair enzymes. Nucleic Acids Research (2015) 43:2271– 2281.
10) Caglayan M.,Batra V.K.,Sassa A.,Prasad R.,WilsonS.H. Role of polymerase β in complementing aprataxin
deficiency during abasic-site base excision repair. Nature Structural and Molecular Biology (2014) 21:497–499.

Considering JEN for your work?

This journal is guided by Melike Caglayan (Associate Professor, University of Nebraska Medical Center, Omaha, Nebraska) and a peer-review board of practising researchers. Open access, author-retained copyright (CC BY), and a clear editorial process.

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