Drug resistance is the capacity of a pathogen, such as a bacterium, virus, fungus, or parasite, or of malignant cells, to withstand the effects of a drug that was previously effective, leading to treatment failure, persistence and spread of infection, and worse clinical outcomes. In microorganisms it arises through …
Drug resistance is the capacity of a pathogen, such as a bacterium, virus, fungus, or parasite, or of malignant cells, to withstand the effects of a drug that was previously effective, leading to treatment failure, persistence and spread of infection, and worse clinical outcomes. In microorganisms it arises through mutation and horizontal gene transfer, producing mechanisms such as target alteration, enzymatic drug inactivation, efflux, and reduced permeability, and is accelerated by selective pressure from inappropriate or incomplete therapy. Antimicrobial resistance is a major global public-health threat that prolongs illness and increases healthcare costs. Research relevant to this area includes rpoB mutations conferring rifampicin resistance in multidrug-resistant tuberculosis with HIV co-infection, HIV drug resistance among antiretroviral-experienced children and adolescents, carbapenem resistance in Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus colonization, antifungal susceptibility of Candida species, malaria as a driver of antibiotic resistance, self-medication and drug-storage practices, and post-COVID mucormycosis. The journal publishes peer-reviewed work in drug-resistant pathogen research addressing the molecular mechanisms, epidemiology, and clinical consequences of antimicrobial and therapeutic resistance, connecting studies of resistant bacteria, viruses, and fungi to surveillance, stewardship, and strategies to preserve the effectiveness of existing treatments.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 44 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Drug Resistance, linking to each citing work.