Tauheed Ishrat
University of Tennessee Health Science Center, United States · united states
Editorial leadership for Journal of Advanced Pharmaceutical Science And Technology ISSN 2328-0182
Research interests
- My Research Interests Focus On The Molecular Events Underlying Neurological Diseases. In My Studies I Concentrate On Three Diseases: Parkinson
- Alzheimer
- Cerebral Stroke. The Long-Term Goal To Identify Potential New Drug Targets For The Development Of Causative Treatments. These Are Progressive Diseases Of The Nervous System Involving Damage Or Loss Of Neurons In The Brain. The Causes Of The Diseases Are Unknown But Recent Evidence Suggests A Multifactorial Origin Involving Genetic
- Environmental Factors. Considerable Efforts Have Been Made To Determine The Cellular Mechanisms That Might Underlie The Cell Death In These Diseases. Over The Years
- Several Pathogenic Hypotheses Have Been Proposed
- Including Oxidative Stress
- Apoptosis
- Excitotoxicity
- Inflammation
- Mitochondrial Dysfunction. However
- Up To Now It Is Not Known Which Of These Metabolic Pathways Participate In The Process Of Cell Death
- If
- How They Interact
- Which Genes Are Regulating This Complex Network
Biography
Dr. Tauheed Ishrat is a research scientist at the University of Tennessee Health Science Center, United States, with over 12 indexed publications. His research focuses on vascular protection during the acute stroke period to improve outcomes in ischemic stroke, and he works to identify strategies for reducing vascular damage following ischemic events with the goal of developing novel therapies for stroke patients. His most-cited work, "Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication" (2018), has received 145 citations and reflects his contributions to understanding molecular mechanisms in cerebrovascular and neurodegenerative conditions.
Selected publications
- Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication 2018 cited 145×
- Tissue Plasminogen Activator Promotes TXNIP-NLRP3 Inflammasome Activation after Hyperglycemic Stroke in Mice 2020 cited 41×
- The Brain AT2R—a Potential Target for Therapy in Alzheimer’s Disease and Vascular Cognitive Impairment: a Comprehensive Review of Clinical and Experimental Therapeutics 2020 cited 30×
- Verapamil Prevents Development of Cognitive Impairment in an Aged Mouse Model of Sporadic Alzheimer’s Disease 2021 cited 22×
- Verapamil inhibits TXNIP-NLRP3 inflammasome activation and preserves functional recovery after intracerebral hemorrhage in mice 2022 cited 21×
- Verapamil as an Adjunct Therapy to Reduce tPA Toxicity in Hyperglycemic Stroke: Implication of TXNIP/NLRP3 Inflammasome 2021 cited 21×
Ranked by citation impact (Crossref) where available, newest otherwise · verified via ORCID.
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This journal is guided by Tauheed Ishrat (University of Tennessee Health Science Center, United States) and a peer-review board of practising researchers. Open access, author-retained copyright (CC BY), and a clear editorial process.