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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">IJGP</journal-id>
      <journal-title-group>
        <journal-title>International Journal of General Practice</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2692-5257</issn>
      <publisher>
        <publisher-name>Open Access Pub</publisher-name>
        <publisher-loc>United States</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.14302/issn.2692-5257.ijgp-24-5041</article-id>
      <article-id pub-id-type="publisher-id">IJGP-24-5041</article-id>
      <article-categories>
        <subj-group>
          <subject>thesis-article </subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Exploring HIV Self-Testing: Barriers and Facilitators among Undergraduate Students</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Nicholas</surname>
            <given-names>Muendo</given-names>
          </name>
          <xref ref-type="aff" rid="idm1849493180">1</xref>
          <xref ref-type="aff" rid="idm1849509212">*</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Joseph</surname>
            <given-names>Thigiti</given-names>
          </name>
          <xref ref-type="aff" rid="idm1849492100">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Osborn</surname>
            <given-names>Tembu</given-names>
          </name>
          <xref ref-type="aff" rid="idm1849491956">3</xref>
        </contrib>
      </contrib-group>
      <aff id="idm1849493180">
        <label>1</label>
        <addr-line>Department of Family Medicine, Kenyatta University.</addr-line>
      </aff>
      <aff id="idm1849492100">
        <label>2</label>
        <addr-line>Faculty of Medicine, Kenyatta University</addr-line>
      </aff>
      <aff id="idm1849491956">
        <label>3</label>
        <addr-line>P.o Box 28198-00200, Nairobi, Kenya</addr-line>
      </aff>
      <aff id="idm1849509212">
        <label>*</label>
        <addr-line>Corresponding Author</addr-line>
      </aff>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Kapriolzzf</surname>
            <given-names/>
          </name>
          <xref ref-type="aff" rid="idm1849351420">1</xref>
        </contrib>
      </contrib-group>
      <aff id="idm1849351420">
        <label>1</label>
        <addr-line>Flapper mod, Sweden</addr-line>
      </aff>
      <author-notes>
        <corresp>
    
    Nicholas Muendo, <addr-line>Department of Family Medicine, Kenyatta University</addr-line>, <email>nickkmuendo@gmail.com</email></corresp>
        <fn fn-type="conflict" id="idm1842588748">
          <p>The authors have declared that no competing interests exist.</p>
        </fn>
      </author-notes>
      <pub-date pub-type="epub" iso-8601-date="2024-04-20">
        <day>20</day>
        <month>04</month>
        <year>2024</year>
      </pub-date>
      <volume>1</volume>
      <issue>3</issue>
      <fpage>16</fpage>
      <lpage>25</lpage>
      <history>
        <date date-type="received">
          <day>21</day>
          <month>03</month>
          <year>2024</year>
        </date>
        <date date-type="accepted">
          <day>17</day>
          <month>04</month>
          <year>2024</year>
        </date>
        <date date-type="online">
          <day>20</day>
          <month>04</month>
          <year>2024</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>© </copyright-statement>
        <copyright-year>2024</copyright-year>
        <copyright-holder>Nicholas Muendo, et al</copyright-holder>
        <license xlink:href="http://creativecommons.org/licenses/by/4.0/" xlink:type="simple">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="http://openaccesspub.org/ijgp/article/2103">This article is available from http://openaccesspub.org/ijgp/article/2103</self-uri>
      <abstract>
        <sec id="idm1849357180">
          <title>Introduction</title>
          <p>Globally, 36.7 million individuals live with HIV/AIDS, with 2.5 million new cases annually. Youth (14-25 years) account for 45% of these new infections. Those aged 15-24 years are less likely to be aware of their HIV status and engage in HIV care compared to older adults. This study explores the use of HIV self-testing to improve access to HIV care among Kenyatta University                undergraduates.</p>
        </sec>
        <sec id="idm1849355236">
          <title>Objective</title>
          <p>To identify barriers and facilitators to HIV self-testing in this group.</p>
        </sec>
        <sec id="idm1849354300">
          <title>Methodology</title>
          <p>Employing multistage cluster sampling, 398 students were                       surveyed using a self-administered questionnaire.</p>
        </sec>
        <sec id="idm1849355092">
          <title>Results</title>
          <p>Of the participants (median age 21 years, 1:1.03 male-to-female ratio), 91.7% understood HIV's seriousness, with sexual intercourse as the primary  transmission mode. Self-testing usage was 28.8%. Key barriers included fear of partner reaction, stigma, and lack of confidence. Significant facilitators were                being female, knowledgeable about HIV, and sexually active.</p>
        </sec>
        <sec id="idm1849355812">
          <title>Conclusion</title>
          <p>Only 24% had prior HIV testing experience. The study highlights the importance of addressing fears and misconceptions while leveraging knowledge and sexual activity awareness to promote HIV self-testing.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>HIVST</kwd>
        <kwd>UNDERGRADUATE</kwd>
        <kwd>HIV</kwd>
      </kwd-group>
      <counts>
        <fig-count count="2"/>
        <table-count count="7"/>
        <page-count count="10"/>
      </counts>
    </article-meta>
  </front>
  <body>
    <sec id="idm1849354876" sec-type="intro">
      <title>Introduction</title>
      <p>Globally, 36.7 million people live with HIV/AIDS, and annually, 2.5 million new infections are reported. Notably, 45% of these infections are among youth aged 14 to 25, with university students at high risk due to behaviour’s like                            cross-generational sexual relationships, escalating the spread of HIV/AIDS and other sexually transmitted diseases<xref ref-type="bibr" rid="ridm1849258780">1</xref><xref ref-type="bibr" rid="ridm1849262308">2</xref>. HIV self-testing (HIVST) offers a private means for individuals, particularly university students, to test for HIV, thus               enhancing testing access for high-risk groups <xref ref-type="bibr" rid="ridm1849270956">3</xref>. This method detects HIV-1 p24 antigen or HIV-1/2 antibodies, requiring healthcare confirmation for positive  results and has a specificity of 99.9% <xref ref-type="bibr" rid="ridm1849336540">4</xref>. In Kenya, HIV/AIDS prevalence is                noteworthy, with a 3.7% rate among adults aged 15 to 49, emphasizing the virus's significant impact, especially on the young population. This highlights the need for continued research and interventions <xref ref-type="bibr" rid="ridm1849328908">5</xref>. Despite the importance, HIV testing and linkage to care among adolescents and young adults are low, hindering epidemic control<xref ref-type="bibr" rid="ridm1849270956">3</xref>.                     Insufficient awareness of HIV status and late treatment initiation among youth are leading to more  infections<xref ref-type="bibr" rid="ridm1849121916">6</xref>. HIVST could bridge testing gaps and foster preventive practices <xref ref-type="bibr" rid="ridm1849119756">7</xref>. This study investigates the obstacles to HIV testing among a demographic highly susceptible to the disease.</p>
    </sec>
    <sec id="idm1849352212" sec-type="materials">
      <title>Materials and Methods</title>
      <p>The study, a cross-sectional descriptive analysis, was conducted at Kenyatta University's main campus in Nairobi, Kenya. This campus was selected for its diverse student population.</p>
      <p>A multi-stage cluster sampling method was used, selecting random clusters within faculties or schools. This approach was chosen to effectively represent the university's large and dispersed undergraduate population. The sample size, determined using Fischer's formula, was set at 398, accounting for a 95% confidence level, a 55% target characteristic proportion, and a 5% precision degree.</p>
      <p>Participants included undergraduates aged 18-25 years at the main campus, excluding those who were HIV positive and on treatment or taking end-of-semester/year exams. Data collection involved                      self-administered questionnaires with both open and closed questions, piloted at the Parklands                     campus.Data analysis was quantitative, focusing on descriptive analysis and quantitative methods to explore variable relationships <xref ref-type="bibr" rid="ridm1849123572">8</xref><xref ref-type="bibr" rid="ridm1849108700">9</xref>. Ethical approval was obtained from the Kenyatta University ethics committee, and participant confidentiality was ensured.</p>
    </sec>
    <sec id="idm1849352068" sec-type="results">
      <title>Results</title>
      <p>The average age of the participants was 21.1 years, with a majority being single, female, Christian,              full-time students majoring in Education, and living off-campus (<xref ref-type="table" rid="idm1842287916">Table 1</xref>).</p>
      <table-wrap id="idm1842287916">
        <label>Table 1.</label>
        <caption>
          <title> Socio-Demographic Characteristics of the Study Participants</title>
        </caption>
        <table rules="all" frame="box">
          <tbody>
            <tr>
              <td>
                <bold>Socio-Demographic</bold>
                <bold>Characteristics</bold>
              </td>
              <td>
                <bold>Frequency</bold>
                <italic>,</italic>
                <italic>n=398</italic>
              </td>
              <td>
                <bold>Percent%</bold>
              </td>
            </tr>
            <tr>
              <td>
                <bold>Age</bold>
                <bold>(Years)</bold>
              </td>
              <td> </td>
              <td> </td>
            </tr>
            <tr>
              <td>18 – 21</td>
              <td>257</td>
              <td>64.6</td>
            </tr>
            <tr>
              <td>22 – 25</td>
              <td>141</td>
              <td>35.4</td>
            </tr>
            <tr>
              <td>
                <bold>Gender</bold>
              </td>
              <td> </td>
              <td> </td>
            </tr>
            <tr>
              <td>Male</td>
              <td>196</td>
              <td>49.2</td>
            </tr>
            <tr>
              <td>Female</td>
              <td>202</td>
              <td>50.8</td>
            </tr>
            <tr>
              <td>
                <bold>Marital</bold>
                <bold>status</bold>
              </td>
              <td> </td>
              <td> </td>
            </tr>
            <tr>
              <td>Single</td>
              <td>390</td>
              <td>98.0</td>
            </tr>
            <tr>
              <td>Married</td>
              <td>8</td>
              <td>2.0</td>
            </tr>
            <tr>
              <td>
                <bold>Religion</bold>
              </td>
              <td> </td>
              <td> </td>
            </tr>
            <tr>
              <td>Christian</td>
              <td>373</td>
              <td>93.7</td>
            </tr>
            <tr>
              <td>Muslim</td>
              <td>25</td>
              <td>6.3</td>
            </tr>
            <tr>
              <th>
                <bold>Mode</bold>
                <bold>of</bold>
                <bold>study</bold>
              </th>
              <td> </td>
              <td> </td>
            </tr>
            <tr>
              <td>Full time</td>
              <td>391</td>
              <td>98.2</td>
            </tr>
            <tr>
              <td>Part time</td>
              <td>7</td>
              <td>1.8</td>
            </tr>
            <tr>
              <td>
                <bold>Residency</bold>
                <bold>status</bold>
              </td>
              <td> </td>
              <td> </td>
            </tr>
            <tr>
              <td>In school</td>
              <td>137</td>
              <td>34.4</td>
            </tr>
            <tr>
              <td>Out of school</td>
              <td>261</td>
              <td>65.6</td>
            </tr>
            <tr>
              <td>
                <bold>School</bold>
              </td>
              <td> </td>
              <td> </td>
            </tr>
            <tr>
              <td>Environmental Sciences</td>
              <td>7</td>
              <td>1.8</td>
            </tr>
            <tr>
              <td>Business</td>
              <td>71</td>
              <td>17.8</td>
            </tr>
            <tr>
              <td>Hospitality and Tourism</td>
              <td>17</td>
              <td>4.3</td>
            </tr>
            <tr>
              <td>Nursing Sciences</td>
              <td>6</td>
              <td>1.5</td>
            </tr>
            <tr>
              <td>Education</td>
              <td>122</td>
              <td>30.7</td>
            </tr>
            <tr>
              <td>Engineering and Technology</td>
              <td>6</td>
              <td>1.5</td>
            </tr>
            <tr>
              <td>Economics</td>
              <td>29</td>
              <td>7.3</td>
            </tr>
            <tr>
              <td>Agriculture &amp; Enterprise Development</td>
              <td>6</td>
              <td>1.5</td>
            </tr>
            <tr>
              <td>Public Health and Applied Human Sciences</td>
              <td>24</td>
              <td>6.0</td>
            </tr>
            <tr>
              <td>Pure and Applied Sciences</td>
              <td>32</td>
              <td>8.0</td>
            </tr>
            <tr>
              <td>Medicine</td>
              <td>7</td>
              <td>1.8</td>
            </tr>
            <tr>
              <td>Humanities and Social Sciences</td>
              <td>40</td>
              <td>10.1</td>
            </tr>
            <tr>
              <td>Architecture</td>
              <td>6</td>
              <td>1.5</td>
            </tr>
            <tr>
              <td>Creative, Film and Media Studies</td>
              <td>17</td>
              <td>4.3</td>
            </tr>
            <tr>
              <td>Law</td>
              <td>8</td>
              <td>2.0</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <sec id="idm1849285988">
        <title>Barriers to the use of HIV self-testing</title>
        <p>Participants demonstrated substantial knowledge about HIV, recognizing it as a serious disease  primarily transmitted through sexual contact. Nearly half were informed about HIV pre-exposure prophylaxis, the lack of a definitive cure, and the possibility of living a normal life with Highly Active Antiretroviral Therapy (HAART), as detailed in (<xref ref-type="table" rid="idm1842161524">Table 2</xref>). Participants had a favorable view of HIV self-testing; most had been tested within the past three months, including through self-test kits. While                       facility-based testing (VCT) was prevalent, a significant portion preferred the OraQuick self-test kit (<xref ref-type="table" rid="idm1842089556">Table 3</xref>). Among the 97 participants who used HIV self-testing, routine use and protecting loved ones were primary motivations. The predominant reason for avoiding testing was the fear of a positive result (<xref ref-type="fig" rid="idm1842015164">Figure 1</xref>), while fear of stigmatization was the main obstacle to facility-based testing (<xref ref-type="fig" rid="idm1842043964">Figure 2</xref>).</p>
        <table-wrap id="idm1842161524">
          <label>Table 2.</label>
          <caption>
            <title> Knowledge about HIV (HIV as a Serious Disease)</title>
          </caption>
          <table rules="all" frame="box">
            <tbody>
              <tr>
                <td>
                  <bold>HIV/AIDS</bold>
                  <bold>is a serious</bold>
                  <bold>disease</bold>
                </td>
                <td>
                  <bold>Frequency</bold>
                  <italic>,</italic>
                  <italic>n=398</italic>
                </td>
                <td>
                  <bold>Percent %</bold>
                </td>
              </tr>
              <tr>
                <td>Yes</td>
                <td>364</td>
                <td>91.5</td>
              </tr>
              <tr>
                <td>No</td>
                <td>18</td>
                <td>4.5</td>
              </tr>
              <tr>
                <td>Unsure</td>
                <td>16</td>
                <td>4.0</td>
              </tr>
              <tr>
                <td>
                  <bold>How HIV is spread</bold>
                </td>
                <td>
                  <italic> </italic>
                </td>
                <td>
                  <italic> </italic>
                </td>
              </tr>
              <tr>
                <td>Sexually</td>
                <td>390</td>
                <td>98.0</td>
              </tr>
              <tr>
                <td>Mother to Child</td>
                <td>349</td>
                <td>87.7</td>
              </tr>
              <tr>
                <td>Blood Transfusion</td>
                <td>327</td>
                <td>82.2</td>
              </tr>
              <tr>
                <td>Intravenous Drug Abuse</td>
                <td>180</td>
                <td>45.2</td>
              </tr>
              <tr>
                <th>
                  <bold>Aware</bold>
                  <bold>of Pre-exposure prophylaxis</bold>
                </th>
                <td>
                  <italic> </italic>
                </td>
                <td>
                  <bold> </bold>
                </td>
              </tr>
              <tr>
                <td>Yes</td>
                <td>190</td>
                <td>47.7</td>
              </tr>
              <tr>
                <td>No</td>
                <td>160</td>
                <td>40.2</td>
              </tr>
              <tr>
                <td>Unsure</td>
                <td>48</td>
                <td>12.1</td>
              </tr>
              <tr>
                <th>
                  <bold>HIV</bold>
                  <bold>has</bold>
                  <bold>a cure</bold>
                </th>
                <td> </td>
                <td> </td>
              </tr>
              <tr>
                <td>Yes</td>
                <td>20</td>
                <td>5.0</td>
              </tr>
              <tr>
                <td>No</td>
                <td>341</td>
                <td>85.7</td>
              </tr>
              <tr>
                <td>Unsure</td>
                <td>37</td>
                <td>9.3</td>
              </tr>
              <tr>
                <td>
                  <bold>Live</bold>
                  <bold>normal</bold>
                  <bold>life</bold>
                  <bold>with</bold>
                  <bold>HAART</bold>
                </td>
                <td> </td>
                <td> </td>
              </tr>
              <tr>
                <td>Yes</td>
                <td>316</td>
                <td>79.4</td>
              </tr>
              <tr>
                <td>No</td>
                <td>28</td>
                <td>7.0</td>
              </tr>
              <tr>
                <td>Unsure</td>
                <td>54</td>
                <td>13.6</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <table-wrap id="idm1842089556">
          <label>Table 3.</label>
          <caption>
            <title> HIV Testing Acceptance</title>
          </caption>
          <table rules="all" frame="box">
            <tbody>
              <tr>
                <td>
                  <bold>Ever</bold>
                  <bold>tested for</bold>
                  <bold>HIV</bold>
                </td>
                <td>
                  <bold>Frequency</bold>
                  <italic>,</italic>
                  <italic>n=398</italic>
                </td>
                <td>
                  <bold>Percent%</bold>
                </td>
              </tr>
              <tr>
                <td>Yes</td>
                <td>260</td>
                <td>65.3</td>
              </tr>
              <tr>
                <td>No</td>
                <td>138</td>
                <td>34.7</td>
              </tr>
              <tr>
                <td colspan="3">
                  <bold>Ever</bold>
                  <bold>used</bold>
                  <bold>HIV self-test kit</bold>
                </td>
              </tr>
              <tr>
                <td>Yes</td>
                <td>97</td>
                <td>24.4</td>
              </tr>
              <tr>
                <td>No</td>
                <td>301</td>
                <td>75.6</td>
              </tr>
              <tr>
                <td>
                  <bold>Last</bold>
                  <bold>time</bold>
                  <bold>tested for</bold>
                  <bold>HIV</bold>
                </td>
                <td>
                  <bold>Frequency</bold>
                  <italic>,</italic>
                  <italic>n=260</italic>
                </td>
                <td>
                  <bold>Percent%</bold>
                </td>
              </tr>
              <tr>
                <td>Last 3 months</td>
                <td>69</td>
                <td>26.5</td>
              </tr>
              <tr>
                <td>Last 6 months</td>
                <td>75</td>
                <td>28.8</td>
              </tr>
              <tr>
                <td>More than 1 year ago</td>
                <td>116</td>
                <td>44.6</td>
              </tr>
              <tr>
                <td colspan="3">
                  <bold>Type</bold>
                  <bold>of test</bold>
                  <bold>done</bold>
                  <bold>at</bold>
                  <bold>that</bold>
                  <bold>time</bold>
                </td>
              </tr>
              <tr>
                <td>Facility test (VCT)</td>
                <td> 185</td>
                <td>71.2</td>
              </tr>
              <tr>
                <td>HIV self-testing</td>
                <td>  75</td>
                <td>28.8</td>
              </tr>
              <tr>
                <td>
                  <bold>HIV</bold>
                  <bold>self-test</bold>
                  <bold>used</bold>
                </td>
                <td>
                  <bold> Frequency,</bold>
                  <italic>n=97</italic>
                </td>
                <td>
                  <bold>Percent</bold>
                  <bold>%</bold>
                </td>
              </tr>
              <tr>
                <td>INSTI</td>
                <td>               25</td>
                <td>25.8</td>
              </tr>
              <tr>
                <td>OraQuick</td>
                <td>               59</td>
                <td>60.8</td>
              </tr>
              <tr>
                <td>Atomo HIV self-test</td>
                <td>               13</td>
                <td>13.4</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <fig id="idm1842015164">
          <label>Figure 1.</label>
          <caption>
            <title> HIV Testing Acceptance (Reason not to perform HIV test)</title>
          </caption>
          <graphic xlink:href="images/image1.jpg" mime-subtype="jpg"/>
        </fig>
        <fig id="idm1842043964">
          <label>Figure 2.</label>
          <caption>
            <title> HIV Testing Acceptance (Facility Based HIV Testing Challenge)</title>
          </caption>
          <graphic xlink:href="images/image2.jpg" mime-subtype="jpg"/>
        </fig>
      </sec>
      <sec id="idm1849163732">
        <title>Facilitators to the use of HIV self-testing</title>
        <p>Participants recognizing HIV/AIDS as serious and informed about pre-exposure prophylaxis, as well as those identifying as sexually active, were more inclined to use HIV self-testing (<xref ref-type="table" rid="idm1842043748">Table 4</xref>).</p>
        <table-wrap id="idm1842043748">
          <label>Table 4.</label>
          <caption>
            <title> Sexual behaviour factors</title>
          </caption>
          <table rules="all" frame="box">
            <tbody>
              <tr>
                <td>
                  <bold>Ever</bold>
                  <bold>had</bold>
                  <bold>sex</bold>
                </td>
                <td>
                  <bold>Frequency</bold>
                  <italic>,</italic>
                  <italic>n=398</italic>
                </td>
                <td>
                  <bold>Percent%</bold>
                </td>
              </tr>
              <tr>
                <td>Yes</td>
                <td>278</td>
                <td>69.8</td>
              </tr>
              <tr>
                <td>No</td>
                <td>120</td>
                <td>30.2</td>
              </tr>
              <tr>
                <td colspan="3">
                  <bold>Consider self sexually active</bold>
                  <bold>Consider self sexually active</bold>
                </td>
              </tr>
              <tr>
                <td>Yes</td>
                <td>228</td>
                <td>57.3</td>
              </tr>
              <tr>
                <td>No</td>
                <td>50</td>
                <td>12.6</td>
              </tr>
              <tr>
                <td>Never had sex</td>
                <td>120</td>
                <td>30.2</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <p>Media exposure, notably the "Chukua Selfie" campaign, correlated with higher usage of HIV self-testing. Participants generally favored self-testing and would recommend it to others (<xref ref-type="table" rid="idm1841977332">Table 5</xref>).</p>
        <table-wrap id="idm1841977332">
          <label>Table 5.</label>
          <caption>
            <title> Recommendation of HIVST and knowledge about “Chukua Selfie” HIVST Campaign</title>
          </caption>
          <table rules="all" frame="box">
            <tbody>
              <tr>
                <td><bold>Know</bold><bold>about</bold><bold>campaign</bold><bold>dubbed</bold>“ChukuaSelfie”</td>
                <td>
                  <bold>Frequency</bold>
                  <italic>,</italic>
                  <italic>n=398</italic>
                </td>
                <td>
                  <bold>Percent</bold>
                  <bold>%</bold>
                </td>
              </tr>
              <tr>
                <td>Yes</td>
                <td>189</td>
                <td>47.5</td>
              </tr>
              <tr>
                <td>No</td>
                <td>209</td>
                <td>52.5</td>
              </tr>
              <tr>
                <td>
                  <bold>Recommend</bold>
                  <bold>HIV</bold>
                  <bold>self-testing</bold>
                </td>
                <td>
                  <bold>Frequency</bold>
                  <italic>,</italic>
                  <italic>n=97</italic>
                </td>
                <td> </td>
              </tr>
              <tr>
                <td>Yes</td>
                <td>97</td>
                <td>100.0</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
      <sec id="idm1849120220">
        <title>Comparing barriers with facilitators in the uptake of HIV self-testing</title>
        <p>Comparing barriers and facilitators for HIV self-testing among undergraduates, most participants hadn't used it, and no significant statistical link was found between demographic factors (age, gender, marital status) and self-testing usage (<xref ref-type="table" rid="idm1841928548">Table 6</xref>). However, several facilitators, such as knowledge about HIV/AIDS, awareness of pre- exposure prophylaxis, and considering oneself sexually active, were identified (<xref ref-type="table" rid="idm1841885132">Table 7</xref>)</p>
        <table-wrap id="idm1841928548">
          <label>Table 6.</label>
          <caption>
            <title> Barriers to the use of the HIV self-testing</title>
          </caption>
          <table rules="all" frame="box">
            <tbody>
              <tr>
                <td>
                  <bold>Barriers</bold>
                  <bold>to</bold>
                  <bold>the</bold>
                  <bold>use</bold>
                  <bold>of</bold>
                  <bold>the</bold>
                  <bold>HIV</bold>
                  <bold>self-testing</bold>
                </td>
                <td><bold>Ever</bold><bold>used,</bold>n=97</td>
                <td><bold>Never</bold><bold>used,</bold>n=301</td>
                <td>
                  <bold>OR</bold>
                  <bold>(95%</bold>
                  <bold>CI)</bold>
                </td>
                <td>
                  <bold>p-value</bold>
                </td>
              </tr>
              <tr>
                <td>
                  <bold>Age (Years)</bold>
                </td>
                <td> </td>
                <td> </td>
                <td> </td>
                <td> </td>
              </tr>
              <tr>
                <td>18 – 21</td>
                <td>60 (61.9)</td>
                <td>197 (65.4)</td>
                <td>
                  <bold>Reference</bold>
                </td>
                <td> </td>
              </tr>
              <tr>
                <td>22 – 25</td>
                <td>37 (38.1)</td>
                <td>104 (34.6)</td>
                <td>1.2 (0.7 – 1.9)</td>
                <td>0.520</td>
              </tr>
              <tr>
                <td>
                  <bold>Gender</bold>
                </td>
                <td> </td>
                <td> </td>
                <td> </td>
                <td> </td>
              </tr>
              <tr>
                <td>Male</td>
                <td>40 (41.2)</td>
                <td>156 (51.8)</td>
                <td>
                  <bold>Reference</bold>
                </td>
                <td> </td>
              </tr>
              <tr>
                <td>Female</td>
                <td>57 (58.8)</td>
                <td>145 (48.2)</td>
                <td>1.5 (1.0 – 2.4)</td>
                <td>0.071</td>
              </tr>
              <tr>
                <td>
                  <bold>Marital</bold>
                  <bold>status</bold>
                </td>
                <td> </td>
                <td> </td>
                <td> </td>
                <td> </td>
              </tr>
              <tr>
                <td>Single</td>
                <td>94 (96.9)</td>
                <td>296 (98.3)</td>
                <td>
                  <bold>Reference</bold>
                </td>
                <td> </td>
              </tr>
              <tr>
                <td>Married</td>
                <td>3 (3.1)</td>
                <td>5 (1.7)</td>
                <td>1.9 (0.4 – 8.1)</td>
                <td>0.390</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <table-wrap id="idm1841885132">
          <label>Table 7.</label>
          <caption>
            <title> Facilitators to the use of the HIV self-testing</title>
          </caption>
          <table rules="all" frame="box">
            <tbody>
              <tr>
                <td> </td>
                <td>
                  <bold>Ever</bold>
                  <bold>used,</bold>
                  <italic>n=97</italic>
                </td>
                <td>
                  <bold>Never</bold>
                  <bold>used,</bold>
                  <italic>n=301</italic>
                </td>
                <td>
                  <bold>OR</bold>
                  <bold>(95%</bold>
                  <bold>CI)</bold>
                </td>
                <td>
                  <bold>p-value</bold>
                </td>
              </tr>
              <tr>
                <td colspan="5">KnowledgeaboutHIV</td>
              </tr>
              <tr>
                <td colspan="5">
                  <bold>HIV/AIDS is a </bold>
                  <bold>serious</bold>
                  <bold>disease</bold>
                </td>
              </tr>
              <tr>
                <td>Yes</td>
                <td>93 (95.9)</td>
                <td>271 (90.0)</td>
                <td>1.2 (0.4 – 3.7)</td>
                <td>0.752</td>
              </tr>
              <tr>
                <td>No</td>
                <td>4 (4.1)</td>
                <td>14 (4.7)</td>
                <td>Reference</td>
                <td> </td>
              </tr>
              <tr>
                <td>Unsure</td>
                <td>0 (0.0)</td>
                <td>16 (5.3)</td>
                <td>-</td>
                <td> </td>
              </tr>
              <tr>
                <td colspan="5">
                  <bold>Aware</bold>
                  <bold>of HIV </bold>
                  <bold>Pre-</bold>
                  <bold>exposure</bold>
                  <bold>prophylaxis</bold>
                </td>
              </tr>
              <tr>
                <td>Yes</td>
                <td>64 (66.0)</td>
                <td>126 (41.9)</td>
                <td>3.4 (1.9 – 5.8)</td>
                <td>
                  <bold>&lt;0.001</bold>
                </td>
              </tr>
              <tr>
                <td>No</td>
                <td>21 (21.6)</td>
                <td>139 (46.2)</td>
                <td>Reference</td>
                <td> </td>
              </tr>
              <tr>
                <td>Unsure</td>
                <td>12 (12.4)</td>
                <td>36 (12.0)</td>
                <td>2.2 (1.0 – 4.9)</td>
                <td>0.052</td>
              </tr>
              <tr>
                <td colspan="5"><bold>HIV</bold><bold>has</bold><bold>a cure </bold>       </td>
              </tr>
              <tr>
                <td>Yes</td>
                <td>3 (3.1)</td>
                <td>17 (5.6)</td>
                <td>0.5 (0.1 – 1.7)</td>
                <td>0.288</td>
              </tr>
              <tr>
                <td>No</td>
                <td>88 (90.7)</td>
                <td>253 (84.1)</td>
                <td>Reference</td>
                <td> </td>
              </tr>
              <tr>
                <td>Unsure</td>
                <td>6 (6.2)</td>
                <td>31 (10.3)</td>
                <td>0.6 (0.2 – 1.4)</td>
                <td>0.205</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
    </sec>
    <sec id="idm1849047188" sec-type="discussion">
      <title>Discussion</title>
      <p>The study, mainly involving undergraduate students aged 18-21, may best represent this demographic. With almost equal gender representation, findings could apply to both males and females, echoing Hatzold et al.'s discovery of first-time testers among 16-24-year-olds <xref ref-type="bibr" rid="ridm1849112660">10</xref>. The high number of single, predominantly Christian participants indicates a focus on sexual activity and underlines the need for tailored HIV testing and prevention interventions, as also noted in studies by Buldeo et al. and others <xref ref-type="bibr" rid="ridm1849097652">11</xref>. The participants' status as full-time students suggests school-based interventions might effectively                   promote HIV testing and prevention, supported by evidence from relevant meta-analysis and systematic reviews <xref ref-type="bibr" rid="ridm1849094412">12</xref>. The dependence on family financial support, versus government or employment funding, underscores the importance of family in HIV prevention and aligns with findings from <xref ref-type="bibr" rid="ridm1849089876">13</xref>Basset et al., stressing the need to address financial barriers in healthcare access.</p>
      <sec id="idm1849040404">
        <title>Barriers to the use of HIV self-testing</title>
        <p>The study revealed satisfactory HIV/AIDS knowledge among participants, contrasting a Malaysian study showing limited understanding of non-HIV STDs and alarming risky behaviors <xref ref-type="bibr" rid="ridm1849083132">14</xref>. This aligns with a Sudanese study where sexually active students showed willingness to engage in safe sex                    practices <xref ref-type="bibr" rid="ridm1849076652">15</xref>. A significant number had undergone HIV testing, reflecting a positive testing attitude,                similar to S. Marks et al.'s findings on HIV self-testing preferences among young men<xref ref-type="bibr" rid="ridm1849074564">16</xref>. Major barriers identified were fear of positive results and access to self-test kits, paralleling Y. Qin et al.'s study, which found HIVST reduced stigma <xref ref-type="bibr" rid="ridm1849069812">17</xref>. Risky sexual behavior among some participants highlighted the need for enhanced safe sex promotion. Stigma was a barrier, resonating with Clifton et al.'s study on HIV risk perception and testing behavior in the British population, revealing a disconnect between perceived risk and testing behavior<xref ref-type="bibr" rid="ridm1849085508">18</xref> .</p>
      </sec>
      <sec id="idm1849040764">
        <title>Facilitators to the use of HIV self-testing</title>
        <p>The study found participants generally had positive attitudes towards those living with HIV, though some harbored fears and misconceptions. Media, especially social media, effectively raised HIV                   self-testing (HIVST) awareness, echoing Birdthistle et al.'s findings on the impact of a multimedia        campaign in South Africa<xref ref-type="bibr" rid="ridm1849050588">19</xref>. Participants valued the privacy and ease of interpreting self-test results at home. Accessibility and affordability of self-test kits were key, aligning with Y. Qin et al.'s research on reducing stigma through HIVST<xref ref-type="bibr" rid="ridm1849083132">14</xref>. Repeat usage willingness was high among past self-test users,                  similar to the "4 Youth by Youth" Nigerian study by Iwelunmor et al. emphasizing youth engagement in HIV prevention<xref ref-type="bibr" rid="ridm1849049364">20</xref>. Facilitators like HIV prevention education, routine testing, and protecting loved ones were also noted, supported by a study among African-American youths in North Carolina, highlighting these factors as enablers for self-testing <xref ref-type="bibr" rid="ridm1849042668">21</xref>.</p>
      </sec>
      <sec id="idm1849039612">
        <title>Barriers compared with facilitators in the uptake of HIV self-testing services</title>
        <p>The study showed 24% of participants had used HIV self-test kits, a moderate uptake akin to findings in Malawi and Zimbabwe among young people<xref ref-type="bibr" rid="ridm1849041948">22</xref>. Female students' usage of self-testing was higher but not statistically significant, contrasting with Kenya AIDS Indicator Survey's higher reported testing in                   adolescent girls and young women<xref ref-type="bibr" rid="ridm1849038636">23</xref>. Sexually active individuals were more inclined to use self-test kits, paralleling Izizag. B et al.'s findings on high acceptability among university students<xref ref-type="bibr" rid="ridm1849036404">24</xref>. A tendency emerged where those with negative attitudes towards HIV-positive people were less likely to self-test, diverging from Kumwenda et al.'s study, which highlighted fears of relationship strain due to                          HIV-discordant results in couples<xref ref-type="bibr" rid="ridm1849030668">25</xref>.</p>
      </sec>
    </sec>
    <sec id="idm1849038172" sec-type="conclusions">
      <title>Conclusion</title>
      <p>The study highlighted barriers and facilitators to HIV self-testing among Kenyatta University                         undergraduates, offering insights for interventions to boost self-testing uptake and enhance HIV prevention and care. Key barriers included fear of positive results, access challenges, and HIV stigma, while positive attitudes and media exposure were facilitators. Strategies should focus on reducing stigma,  increasing self-test kit accessibility and affordability, improving counseling services, and addressing gender disparities in testing. HIV self-testing is advised as a supplementary approach to facility-based testing, with a need to monitor its long-term effects on prevention and treatment.</p>
    </sec>
  </body>
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