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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JDOI</journal-id>
      <journal-title-group>
        <journal-title>Journal of Dentistry And Oral Implants</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2473-1005</issn>
      <publisher>
        <publisher-name>Open Access Pub</publisher-name>
        <publisher-loc>United States</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">JDOI-20-3659</article-id>
      <article-id pub-id-type="doi">10.14302/issn.2473-1005.jdoi-20-3659</article-id>
      <article-categories>
        <subj-group>
          <subject>research-article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Digital Planning for Mini-Implant Supported Palatal Expander in Open-Bite Treatment</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Szuhanek</surname>
            <given-names>C</given-names>
          </name>
          <xref ref-type="aff" rid="idm1850555044">1</xref>
          <xref ref-type="aff" rid="idm1850557276">*</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Babat</surname>
            <given-names>M</given-names>
          </name>
          <xref ref-type="aff" rid="idm1850556844">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Popa</surname>
            <given-names>A</given-names>
          </name>
          <xref ref-type="aff" rid="idm1850555044">1</xref>
        </contrib>
      </contrib-group>
      <aff id="idm1850555044">
        <label>1</label>
        <addr-line>Department of Orthodontics, Faculty of Dental Medicine, University of Medicine and Pharmacy ‘Victor Babes’, Timisoara, Romania </addr-line>
      </aff>
      <aff id="idm1850556844">
        <label>2</label>
        <addr-line>Faculty of Dental Medicine, University of Medicine and Pharmacy ‘Victor Babes’, Timisoara, Romania</addr-line>
      </aff>
      <aff id="idm1850557276">
        <label>*</label>
        <addr-line>Corresponding author</addr-line>
      </aff>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Sasho</surname>
            <given-names>Stoleski</given-names>
          </name>
          <xref ref-type="aff" rid="idm1850401036">1</xref>
        </contrib>
      </contrib-group>
      <aff id="idm1850401036">
        <label>1</label>
        <addr-line>Institute of Occupational Health of R. Macedonia, WHO CC and Ga2len CC, Macedonia.</addr-line>
      </aff>
      <author-notes>
        <corresp>
    
    Szuhanek C, <addr-line>Department of Orthodontics, Faculty of Dental Medicine, University of Medicine and Pharmacy ‘Victor Babes’, Timisoara, Romania</addr-line>, Email: <email>camelia.szuhanek@yahoo.com</email></corresp>
        <fn fn-type="conflict" id="idm1849621244">
          <p>The authors have declared that no competing interests exist.</p>
        </fn>
      </author-notes>
      <pub-date pub-type="epub" iso-8601-date="2020-12-21">
        <day>21</day>
        <month>12</month>
        <year>2020</year>
      </pub-date>
      <volume>2</volume>
      <issue>3</issue>
      <fpage>16</fpage>
      <lpage>22</lpage>
      <history>
        <date date-type="received">
          <day>09</day>
          <month>12</month>
          <year>2020</year>
        </date>
        <date date-type="accepted">
          <day>15</day>
          <month>12</month>
          <year>2020</year>
        </date>
        <date date-type="online">
          <day>21</day>
          <month>12</month>
          <year>2020</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>© </copyright-statement>
        <copyright-year>2020</copyright-year>
        <copyright-holder>Szuhanek C, et al.</copyright-holder>
        <license xlink:href="http://creativecommons.org/licenses/by/4.0/" xlink:type="simple">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="http://openaccesspub.org/jdoi/article/1528">This article is available from http://openaccesspub.org/jdoi/article/1528</self-uri>
      <abstract>
        <p>Open bite malocclusion, due to it’s multifactorial etiology, has always been considered a difficult problem to treat. Often associated with transverse maxillary deficiency, this is a real challenge in the field of orthodontics. The traditional approach, for this type of anomaly, in adult patients, is orthognathic surgery and RME (rapid maxillary expansion). There are several approaches to the treatment of adult patients using digital technology. Mini-implant supported palatal expander limits the side effects of the conventional RME and is less invasive compared to orthognathic surgery. Precise and predictable mini-implant insertion, using a customized surgical guide, provides a safe therapeutic approach. This case report combines Cone-beam computed     tomography (CBCT), laser scan superimposition, computer-aided design (CAD) and 3D printing in order to design and print a customized surgical guide for orthodontic mini-implant insertion. A CBCT scan was performed to determine the optimal site for mini-implants’ placement. Using the 3Shape Trios Intraoral Scanner the maxilla and the mandible were laser-scanned. Blue Sky Plan 4 software was used to design the surgical guide, and RayWare software was used for printing it. 4 mini-implants were inserted using a safe and predictable           technique. The 3D technology represents the future of orthodontics, reducing the risks, chair-side time while providing the best treatment plan for the patient.</p>
      </abstract>
      <kwd-group>
        <kwd>mini-implant</kwd>
        <kwd>open-bite treatment</kwd>
      </kwd-group>
      <counts>
        <fig-count count="7"/>
        <table-count count="0"/>
        <page-count count="7"/>
      </counts>
    </article-meta>
  </front>
  <body>
    <sec id="idm1850398804" sec-type="intro">
      <title>Introduction</title>
      <p>Open bite is an anomaly with distinct            characteristics that can be easily recognized in 25 to 38 % of the orthodontic patients <xref ref-type="bibr" rid="ridm1842900716">1</xref>. Several etiological factors are responsible for this type of malocclusion such as: facial growth pattern, sucking habits,                       tongue-thrusting, mouth breathing, adenoid               hypertrophy, syndromes, occlusal and eruptive forces, dental ankylosis, and postural mandibular imbalance. <xref ref-type="bibr" rid="ridm1842970260">2</xref> Open bite is often associated with transverse maxillary deficiency, one of the most common malocclusions in orthodontics. <xref ref-type="bibr" rid="ridm1842913724">3</xref></p>
      <p>Rapid maxillary expansion (RME) is the  treatment of choice for the transverse maxillary deficiencies and it is achieved through the remodeling of the midpalatal and inter-maxillary sutures, in children and teenagers. <xref ref-type="bibr" rid="ridm1842973788">4</xref><xref ref-type="bibr" rid="ridm1842760452">5</xref></p>
      <p>Due to the increased inter-digitation of the maxillary sutures and the rigidity of adjacent structures, the prognosis is not that favorable for adult patients. <xref ref-type="bibr" rid="ridm1842758220">6</xref> Root resorptions,damage to periodontal tissues,<xref ref-type="bibr" rid="ridm1842750076">7</xref><xref ref-type="bibr" rid="ridm1842755476">8</xref><xref ref-type="bibr" rid="ridm1842741764">9</xref> technique failure or limitations,<xref ref-type="bibr" rid="ridm1842738956">10</xref> reduced               stability, <xref ref-type="bibr" rid="ridm1842742916">11</xref> edemas and soft tissue lesions <xref ref-type="bibr" rid="ridm1842720244">12</xref> have been reported as side effects for adult patients.</p>
      <p>In order to minimize the side effects of classical RME and to optimize the potential for skeletal expansion in adult patients Lee et al proposed a mini-screw assisted rapid palatal expansion (MARPE) appliance. <xref ref-type="bibr" rid="ridm1842713764">13</xref> Mini-screw insertion site is critical and requires careful consideration of the hard and soft tissue, biomechanics, accessibility and patients’s comfort.</p>
      <p>Digital technology plays a major role in          contemporary orthodontics, changing the rules of conventional workflow. <xref ref-type="bibr" rid="ridm1842727948">14</xref><xref ref-type="bibr" rid="ridm1842726292">15</xref><xref ref-type="bibr" rid="ridm1842693780">16</xref><xref ref-type="bibr" rid="ridm1842691116">17</xref><xref ref-type="bibr" rid="ridm1842688092">18</xref> Every procedure, from diagnosis and treatment outcome pre-visualization to the customization of the appliance design and            customization of the therapy, is more predictable. <xref ref-type="bibr" rid="ridm1842682836">19</xref><xref ref-type="bibr" rid="ridm1842680316">20</xref>. The use of cone beam computer tomography (CBCT) allows for a more detailed diagnosis and selection for an insertion site with adequate bone quantity and quality. The placement of orthodontic              mini-implants with a 3D method based on CBCT imaging has been described in recent years. <xref ref-type="bibr" rid="ridm1842668892">21</xref><xref ref-type="bibr" rid="ridm1842665436">22</xref>.</p>
    </sec>
    <sec id="idm1850404996" sec-type="materials">
      <title>Materials &amp; Methods</title>
      <p>This study presents the 3D planning for a surgical guide in order to place a mini-implant supported maxillary expander.</p>
      <p>In the case presented below, a male patient aged 25 years, with the chief complaint of posterior, skeletal, bilateral cross-bite and anterior open bite, was referred for orthodontic treatment. A rapid palatal expansion appliance was proposed using a skeletal expander anchored on 4 BENEfit® mini-implants.</p>
      <p>A CBCT scan was performed to determine the optimal site for mini-implants’ placement. Using the 3Shape Trios Intraoral Scanner the maxilla and the mandible were laser-scanned (<xref ref-type="fig" rid="idm1842596948">Figure 1</xref>). Blue Sky Plan 4 software was used to design the surgical guide, and RayWare software was used for printing it.</p>
      <fig id="idm1842596948">
        <label>Figure 1.</label>
        <caption>
          <title> Digital models</title>
        </caption>
        <graphic xlink:href="images/image1.jpg" mime-subtype="jpg"/>
      </fig>
      <p>The digital model (stereolitography (STL) files) was superimposed on the CBCT scan (DICOM file (Digital Imaging and Communication in Medicine) file in order to facilitate the optimal positioning of the 4 mini-implants in the anterior hard palate. </p>
    </sec>
    <sec id="idm1850402908" sec-type="results">
      <title>Results</title>
      <p>The most suitable antero-posterior mini-implant placement site is determined based on the width and thickness of the palatal vault. 4 self-drilling mini-implants (BENEfit®) were selected: 2 in the anterior palate (rugae area): 2.0 x 9 mm (ST-33-54209) and 2 in the posterior palate (para-midsagittal area):  2.0 x 7 mm (ST-33-54207). (<xref ref-type="fig" rid="idm1842595436">Figure 2</xref>)</p>
      <fig id="idm1842595436">
        <label>Figure 2.</label>
        <caption>
          <title> Mini-implant characteristics</title>
        </caption>
        <graphic xlink:href="images/image2.jpg" mime-subtype="jpg"/>
      </fig>
      <p>The precise position and angulation of the mini-implants is replicated by 4 cylindrical metallic guides taking into consideration the following parameters: bone thickness, soft tissue thickness and anatomical surrounding structures. The most appropriate site for the placement of mini-implants is: 3 mm lateral to the suture in the first premolar region.  (<xref ref-type="fig" rid="idm1842592484">Figure 3</xref>,<xref ref-type="fig" rid="idm1842592268">Figure 4</xref>)</p>
      <fig id="idm1842592484">
        <label>Figure 3.</label>
        <caption>
          <title> Positioning of the 4 mini-implants, visualized on the basis of the intraoral scan</title>
        </caption>
        <graphic xlink:href="images/image3.jpg" mime-subtype="jpg"/>
      </fig>
      <fig id="idm1842592268">
        <label>Figure 4.</label>
        <caption>
          <title> Positioning of the mini-implants on CBCT, A. Sagittal section, B. Coronal section, C. Axial section</title>
        </caption>
        <graphic xlink:href="images/image4.jpg" mime-subtype="jpg"/>
      </fig>
      <p>A 3D positioning guide was designed on top of the virtual model with the final mini-implant position. (<xref ref-type="fig" rid="idm1842591620">Figure 5</xref>) </p>
      <fig id="idm1842591620">
        <label>Figure 5.</label>
        <caption>
          <title> Designing the surgical guide</title>
        </caption>
        <graphic xlink:href="images/image5.jpg" mime-subtype="jpg"/>
      </fig>
      <p>The customized surgical template was 1.8 mm thick layer offset based on the teeth/mucosa/ bracket contour profiles and ranged from incisors to second premolar. The surgical template was designed to cover the entire occlusal surface. (<xref ref-type="fig" rid="idm1842528076">Figure 6</xref>)</p>
      <fig id="idm1842528076">
        <label>Figure 6.</label>
        <caption>
          <title> Custom made surgical guide with mini-implant analogs final design</title>
        </caption>
        <graphic xlink:href="images/image5.jpg" mime-subtype="jpg"/>
      </fig>
      <p>Patient’s initials are engraved on the outer surface of the guide, as well as the dimensions of the mini-implants in order to provide more safety and not cause confusion during the transfer from the printing office to the dental office (<xref ref-type="fig" rid="idm1842528076">Figure 6</xref>).</p>
      <p>After this stage, this file was exported in RayWare software (<xref ref-type="fig" rid="idm1842525484">Figure 7</xref>) and printed using a autoclavable resin (Surgical Guide-MoonRay).</p>
      <fig id="idm1842525484">
        <label>Figure 7.</label>
        <caption>
          <title> Final preview of the surgical guide before printing</title>
        </caption>
        <graphic xlink:href="images/image6.jpg" mime-subtype="jpg"/>
      </fig>
    </sec>
    <sec id="idm1850382948" sec-type="discussion">
      <title>Discussion</title>
      <p>The digital workflow in orthodontics consists of a triad of digital models, orthodontic software and 3D printers and allows for faster digital case planning, improving communication between professionals and patients without the use of physical documents. In addition, the accessibility and ease of use of this technology enables its wide use in diagnostic and treatment planning. <xref ref-type="bibr" rid="ridm1842660180">23</xref><xref ref-type="bibr" rid="ridm1842672420">24</xref> Three-dimensional image processing allows for virtual planning using CAD (computer-aided design) software as well as CAM (computer-aided manufacturing), such as for the manufacture of surgical guides that were originally used in implantology. <xref ref-type="bibr" rid="ridm1842669180">25</xref><xref ref-type="bibr" rid="ridm1842643652">26</xref>. It is recommended to combine the knowledge of basic sciences and the evolution of new technologies in order to establish safer therapeutic approaches. <xref ref-type="bibr" rid="ridm1842640628">27</xref></p>
      <p>Software-based digital orthodontic planning allows the simulation of the mini-implant placement, determining the ideal characteristics (shape, length, diameter and angulation). It also allows the precise and predictable mini-implant insertion.</p>
    </sec>
    <sec id="idm1850384964" sec-type="conclusions">
      <title>Conclusion</title>
      <p>The 3D technology represents the future of orthodontics, reducing the risks, chair-side time while providing the best treatment plan for the patient.</p>
    </sec>
    <sec id="idm1850382660">
      <title>Acknowledgment </title>
      <p>This research was conducted in the Orthodontic Research Center from Faculty of Dental Medicine, “Victor Babes” University of Medicine and Pharmacy, Timisoara.</p>
    </sec>
  </body>
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