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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">IJGH</journal-id>
      <journal-title-group>
        <journal-title>International Journal of Global Health</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2693-1176</issn>
      <publisher>
        <publisher-name>Open Access Pub</publisher-name>
        <publisher-loc>United States</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.14302/issn.2693-1176.ijgh-20-3612</article-id>
      <article-id pub-id-type="publisher-id">IJGH-20-3612</article-id>
      <article-categories>
        <subj-group>
          <subject>case-report </subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Sudden Death Due to Spontaneous Rupture of the Urinary Bladder following Acute Alcohol Inebriation- A Case report and Review of Literature</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Bikash</surname>
            <given-names>Sah</given-names>
          </name>
          <xref ref-type="aff" rid="idm1843064044">1</xref>
          <xref ref-type="aff" rid="idm1843085764">*</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Shivendra</surname>
            <given-names>Jha</given-names>
          </name>
          <xref ref-type="aff" rid="idm1843082524">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Dikshant</surname>
            <given-names>Pokharel</given-names>
          </name>
          <xref ref-type="aff" rid="idm1843083316">3</xref>
        </contrib>
      </contrib-group>
      <aff id="idm1843064044">
        <label>1</label>
        <addr-line>Associate Professor, Department of Forensic Medicine and Toxicology, B. P. Koirala Institute of Health Sciences, Dharan, Nepal.</addr-line>
      </aff>
      <aff id="idm1843082524">
        <label>2</label>
        <addr-line>Professor, Department of Forensic Medicine and Toxicology, B. P. Koirala Institute of Health Sciences, Dharan, Nepal.</addr-line>
      </aff>
      <aff id="idm1843083316">
        <label>3</label>
        <addr-line>Consultant, Department of Forensic Medicine and Toxicology, Koshi Zonal Hospital, Biratnagar, Nepal.</addr-line>
      </aff>
      <aff id="idm1843085764">
        <label>*</label>
        <addr-line>corresponding author</addr-line>
      </aff>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Qianqian</surname>
            <given-names>song</given-names>
          </name>
          <xref ref-type="aff" rid="idm1842914884">1</xref>
        </contrib>
      </contrib-group>
      <aff id="idm1842914884">
        <label>1</label>
        <addr-line>Wake Forest School of Medicine, Wake Forest Baptist Comprehensive Cancer Center, Medical Center Boulevard, Winston-Salem, NC 27157, United States.</addr-line>
      </aff>
      <author-notes>
        <corresp>
    
    Bikash Sah, <addr-line>Department of Forensic Medicine and Toxicology, B. P. Koirala Institute of Health Sciences, Dharan, Nepal. Postal Code: 56700</addr-line>, Mobile: +9779852062255, Email: <email>bikash.sah@bpkihs.edu</email></corresp>
        <fn fn-type="conflict" id="idm1842000156">
          <p>The authors have declared that no competing interests exist.</p>
        </fn>
      </author-notes>
      <pub-date pub-type="epub" iso-8601-date="2020-11-30">
        <day>30</day>
        <month>11</month>
        <year>2020</year>
      </pub-date>
      <volume>1</volume>
      <issue>3</issue>
      <fpage>1</fpage>
      <lpage>6</lpage>
      <history>
        <date date-type="received">
          <day>29</day>
          <month>10</month>
          <year>2020</year>
        </date>
        <date date-type="accepted">
          <day>23</day>
          <month>11</month>
          <year>2020</year>
        </date>
        <date date-type="online">
          <day>30</day>
          <month>11</month>
          <year>2020</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>© </copyright-statement>
        <copyright-year>2020</copyright-year>
        <copyright-holder>Bikash Sah, et al.</copyright-holder>
        <license xlink:href="http://creativecommons.org/licenses/by/4.0/" xlink:type="simple">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="http://openaccesspub.org//ijgh/article/1509">This article is available from http://openaccesspub.org//ijgh/article/1509</self-uri>
      <abstract>
        <p>Spontaneous rupture of the urinary bladder (SRUB) is a rare clinical condition. Prompt diagnosis is often difficult both clinically and radiologically and necessitates a high index of suspicion as the patients present with non-specific abdominal pain and may not offer a clear history. The depressant effect of alcohol further complicates the diagnosis. We report a case of a young male who was unable to seek medical support and was found dead within 12 hours of the onset of abdominal discomfort following acute alcohol intoxication. At autopsy, rupture of the urinary bladder with blood and blood clots was found in the pelvic cavity with no any corresponding external injury. Spontaneous rupture of the urinary bladder is a rare cause of death in acute alcohol intoxication. In order to further understand this rare condition, the review of related literature has been done.</p>
      </abstract>
      <kwd-group>
        <kwd>Death</kwd>
        <kwd>Diuretics</kwd>
        <kwd>Rupture</kwd>
        <kwd>Urinary Bladder</kwd>
      </kwd-group>
      <counts>
        <fig-count count="3"/>
        <table-count count="1"/>
        <page-count count="6"/>
      </counts>
    </article-meta>
  </front>
  <body>
    <sec id="idm1842912724">
      <title>Background</title>
      <p>Spontaneous rupture of the urinary bladder (SRUB) in affiliation with acute alcohol inebriation driving to death is an uncommon finding<xref ref-type="bibr" rid="ridm1842835972">1</xref>. In common, there are two conceivable clarifications for such rupture, including pathological bladder rupture<xref ref-type="bibr" rid="ridm1842903428">2</xref>,<xref ref-type="bibr" rid="ridm1842915020">3</xref> and idiopathic bladder rupture<xref ref-type="bibr" rid="ridm1842945764">4</xref>.  Spontaneous idiopathic bladder rupture is uncommon and, as the title infers, has no identifiable basic clarification. Idiopathic rupture is experienced in less than 1% of all cases<xref ref-type="bibr" rid="ridm1842701996">5</xref>. Sometimes the idiopathic spontaneous rupture of the bladder is not even diagnosed or suspected amid the victim’s life, being uncovered amid the autopsy<xref ref-type="bibr" rid="ridm1842701996">5</xref>. Persistent spillage of urine does not permit spontaneous closure of the breach<xref ref-type="bibr" rid="ridm1842698972">6</xref> needing urgent suturing through emergency laparotomy. Thus, SRUB could be a surgical crisis and can be quickly lethal if diagnosis and treatment are delayed, with the early intervention being crucial<xref ref-type="bibr" rid="ridm1842698972">6</xref>,<xref ref-type="bibr" rid="ridm1842698036">7</xref>. The condition carries soaring rates of morbidities and fatalities (47%)<xref ref-type="bibr" rid="ridm1842690188">8</xref>, ascribed to the delay in diagnosis. A small number of case reports have been reported in the literature of spontaneous bladder rupture in association with either acute liquor inebriation or recent intake of excessive liquor in the absence of associated injury to the bladder<xref ref-type="bibr" rid="ridm1842835972">1</xref>, <xref ref-type="bibr" rid="ridm1842685148">9</xref><xref ref-type="bibr" rid="ridm1842677084">10</xref><xref ref-type="bibr" rid="ridm1842674564">11</xref><xref ref-type="bibr" rid="ridm1842679604">12</xref><xref ref-type="bibr" rid="ridm1842663020">13</xref><xref ref-type="bibr" rid="ridm1842658052">14</xref><xref ref-type="bibr" rid="ridm1842657116">15</xref>. This study has been done with an objective to report this rare case in order to make the treating doctor aware of this rare surgical emergency condition and also to understand the role of alcohol inebriation in the causation of such rare conditions with the help of reviewing a few available literature. </p>
      <sec id="idm1842918484">
        <title>Case Description</title>
        <p>A 24 years old male with past history of occasional alcohol intake and no any significant medical history had an excessive alcohol intake since the morning of  24<sup>th</sup> July 2019. He was intoxicated which was evident through his falling down on the hotel's floor while walking at around 4:30 pm on the same day and sustained some superficial blunt trauma injuries over his head, face and right forearm region. He experienced abdominal pain similar to that of the acute abdomen for which no medical help was taken. On the next day at around 5 am, he succumbed to death within an hour of intake of water. At autopsy, blood and bloodstains were evident on the urethral meatus, on the medial aspect of left thigh and on undergarment (<xref ref-type="fig" rid="idm1849505300">Figure 1</xref>) with pale appearing skin and oral mucosa at the external examination and approximately 2 liters of blood and blood clots in the pelvic and peritoneal cavity (<xref ref-type="fig" rid="idm1849501700">Figure 2</xref>) as well as ruptured urinary bladder with an intracavitary blood clot (<xref ref-type="fig" rid="idm1849502780">Figure 3</xref>) were seen on internal examination. A careful examination revealed no external injury over the trunk and lower limb regions. </p>
        <fig id="idm1849505300">
          <label>Figure 1.</label>
          <caption>
            <title> Blood stain on thigh and on inner garment</title>
          </caption>
          <graphic xlink:href="images/image1.jpg" mime-subtype="jpg"/>
        </fig>
        <fig id="idm1849501700">
          <label>Figure 2.</label>
          <caption>
            <title> Blood and blood clots in the pelvic cavity</title>
          </caption>
          <graphic xlink:href="images/image2.jpg" mime-subtype="jpg"/>
        </fig>
        <fig id="idm1849502780">
          <label>Figure 3.</label>
          <caption>
            <title> Ruptured Urinary Bladder</title>
          </caption>
          <graphic xlink:href="images/image3.jpg" mime-subtype="jpg"/>
        </fig>
      </sec>
    </sec>
    <sec id="idm1842905492" sec-type="methods">
      <title>Methodology</title>
      <p>The required literature were searched through google scholar and were reviewed. The literature reporting the case of SRUB followed by alcohol intake were included in the review and the literature reporting the case of SRUB with no history of alcohol intake were excluded from the review.</p>
    </sec>
    <sec id="idm1842905708" sec-type="results">
      <title>Results</title>
      <p>During the review of the literature, twelve such cases were found out of which ten cases were saved because of early diagnosis and prompt medical intervention. The findings of the reviewed literature are presented in <xref ref-type="table" rid="idm1849476308">Table 1</xref>.</p>
      <table-wrap id="idm1849476308">
        <label>Table 1.</label>
        <caption>
          <title> Reported cases of SRUB with outcome</title>
        </caption>
        <table rules="all" frame="box">
          <tbody>
            <tr>
              <th>
                <bold>S. No.</bold>
              </th>
              <td>
                <bold>Authors</bold>
              </td>
              <td>
                <bold>Year</bold>
              </td>
              <td>
                <bold>No. of cases</bold>
              </td>
              <td>
                <bold>Outcome</bold>
              </td>
            </tr>
            <tr>
              <td>1</td>
              <td>Bennett  et al<xref ref-type="bibr" rid="ridm1842668132">16</xref></td>
              <td>1980</td>
              <td>1</td>
              <td>Survived</td>
            </tr>
            <tr>
              <td>2</td>
              <td>Munish et al<xref ref-type="bibr" rid="ridm1842658052">14</xref></td>
              <td>1999</td>
              <td>1</td>
              <td>Survived</td>
            </tr>
            <tr>
              <td>3</td>
              <td>Dooldeniya et al<xref ref-type="bibr" rid="ridm1842636180">17</xref></td>
              <td>2007</td>
              <td>3</td>
              <td>All survived</td>
            </tr>
            <tr>
              <td>4</td>
              <td>Parker et al<xref ref-type="bibr" rid="ridm1842634452">18</xref></td>
              <td>2009</td>
              <td>1</td>
              <td>Survived</td>
            </tr>
            <tr>
              <td>5</td>
              <td>Daignutt et al<xref ref-type="bibr" rid="ridm1842633084">19</xref></td>
              <td>2012</td>
              <td>1</td>
              <td>Survived</td>
            </tr>
            <tr>
              <td>6</td>
              <td>Moreno-Alarcon et al<xref ref-type="bibr" rid="ridm1842629124">20</xref></td>
              <td>2014</td>
              <td>1</td>
              <td>Survived</td>
            </tr>
            <tr>
              <td>7</td>
              <td>Muneer et al<xref ref-type="bibr" rid="ridm1842642300">21</xref></td>
              <td>2015</td>
              <td>1</td>
              <td>Survived</td>
            </tr>
            <tr>
              <td>8</td>
              <td>Ioan B et al<xref ref-type="bibr" rid="ridm1842638556">22</xref></td>
              <td>2015</td>
              <td>1</td>
              <td>Died</td>
            </tr>
            <tr>
              <td>9</td>
              <td>Zijoo et al<xref ref-type="bibr" rid="ridm1842701996">5</xref></td>
              <td>2016</td>
              <td>1</td>
              <td>Survived</td>
            </tr>
            <tr>
              <td>10</td>
              <td>Nguyen et al<xref ref-type="bibr" rid="ridm1842624900">23</xref></td>
              <td>2018</td>
              <td>1</td>
              <td>Died</td>
            </tr>
            <tr>
              <td>11</td>
              <td>Present case</td>
              <td>2019</td>
              <td>1</td>
              <td>Died</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
    </sec>
    <sec id="idm1842878740" sec-type="discussion">
      <title>Discussion</title>
      <p>There are very few cases in the literature that portray the occurrence of SRUB due to liquor inebriation in the absence of associated traumatic bladder injury. Herein, we report a rare case of SRUB secondary to liquor inebriation, together with a review of the literatures, for a better understanding of this unusual phenomenon. This case could also have been saved if he could have gone to or have been taken to the hospital at the time he experienced the abdominal pain. Alcohol intake in this present-day world is common. Thus, along with treating doctors, the general public also need to be aware of this type of case. At the same time, different literature have further clarified different important aspects related to such cases. Uysal et al<xref ref-type="bibr" rid="ridm1842945764">4</xref>was unable to find out the reason behind the spontaneous bladder rupture in a 78-year-old female presented with an acute abdomen. In a different case, a 26-year-old male presented with painless progressive abdominal distention; he was able to recoup fully after surgical repair of a spontaneous bladder perforation<xref ref-type="bibr" rid="ridm1842621516">24</xref>. Parker et al. reported that bladder rupture can be associated with an experience of liquor fling<xref ref-type="bibr" rid="ridm1842617268">25</xref>. </p>
      <p>The spontaneous rupture of the bladder can be facilitated by excessive liquor intake which has a diuretic effect<xref ref-type="bibr" rid="ridm1842835972">1</xref> and leads to overdistension from the perspective of the sensitivity disorder due to the α-sympathomimetic effect and CNS depression produced by the liquor. In a male, congestion of the prostate and prostatic urethra exaggerates the obstruction of the outlet<xref ref-type="bibr" rid="ridm1842615756">26</xref>.  However, Dooldeniya et al<xref ref-type="bibr" rid="ridm1842636180">17</xref>reported three female cases with SRUB following liquor intake thus suggested that this type of problem should be considered among women as well. Nausea and vomiting might lead to enhanced intra-abdominal pressure and a higher probability of SRUB<xref ref-type="bibr" rid="ridm1842613236">27</xref>. Saliba et al<xref ref-type="bibr" rid="ridm1842613236">27</xref> suggested that patients presenting with alcohol inebriation and acute abdomen or ascites should be considered for the differential diagnoses of SRUB. </p>
      <p>The review of the literature has clearly shown that most cases of spontaneous bladder rupture in affiliation with liquor intake are treated without complication when diagnosed quickly. Delayed diagnosis has led to considerable morbidity and fatality<xref ref-type="bibr" rid="ridm1842609924">28</xref>. Different studies <xref ref-type="bibr" rid="ridm1842835972">1</xref><xref ref-type="bibr" rid="ridm1842685148">9</xref><xref ref-type="bibr" rid="ridm1842677084">10</xref><xref ref-type="bibr" rid="ridm1842663020">13</xref>have shown that SRUB following liquor inebriation is rare. Despite the infrequency, the cases in the literature retain consistency with regard to features at presentation, course, and appropriate treatment. It is important for treating doctors, especially of the emergency department to be aware of this particular condition due to the diagnostic and subsequent treatment difficulties. At the same time, the professionals in the field of forensic medicine have to consider this entity while giving opinions about the cause of death.</p>
    </sec>
    <sec id="idm1842877516" sec-type="conclusions">
      <title>Conclusions</title>
      <p>This case and the review of literature have shown that most of the cases of SRUB following acute alcohol intoxication can have a positive outcome with early prediction and management whereas some cases primarily discovered during autopsy due to unawareness about it among the general public as well as difficulties of its diagnosis and its rapid evolution.</p>
    </sec>
    <sec id="idm1842854100">
      <title>Source of funding</title>
      <p>The authors received no financial support for the research, authorship, and /or publication of this article.</p>
    </sec>
  </body>
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