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 <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.0 20120330//EN" "http://jats.nlm.nih.gov/publishing/1.0/JATS-journalpublishing1.dtd"> <article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.0" xml:lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">IJCV</journal-id>
      <journal-title-group>
        <journal-title>International Journal of Coronaviruses</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2692-1537</issn>
      <publisher>
        <publisher-name>Open Access Pub</publisher-name>
        <publisher-loc>United States</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.14302/issn.2692-1537.ijcv-20-3453</article-id>
      <article-id pub-id-type="publisher-id">IJCV-20-3453</article-id>
      <article-categories>
        <subj-group>
          <subject>research-article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>A quick Look at the Registered Cases of Covid-19 Throughout the World</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Raul</surname>
            <given-names>Isea</given-names>
          </name>
          <xref ref-type="aff" rid="idm1843006932">1</xref>
          <xref ref-type="aff" rid="idm1843004268">*</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Karl</surname>
            <given-names>E Lonngren</given-names>
          </name>
          <xref ref-type="aff" rid="idm1843004340">2</xref>
        </contrib>
      </contrib-group>
      <aff id="idm1843006932">
        <label>1</label>
        <addr-line>Fundación Instituto de Estudios Avanzados IDEA, Hoyo de la Puerta, Baruta, Venezuela</addr-line>
      </aff>
      <aff id="idm1843004340">
        <label>2</label>
        <addr-line>Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA</addr-line>
      </aff>
      <aff id="idm1843004268">
        <label>*</label>
        <addr-line>Corresponding author</addr-line>
      </aff>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Sasho</surname>
            <given-names>Stoleski</given-names>
          </name>
          <xref ref-type="aff" rid="idm1843122052">1</xref>
        </contrib>
      </contrib-group>
      <aff id="idm1843122052">
        <label>1</label>
        <addr-line>Institute of Occupational Health of R. Macedonia, WHO CC and Ga2len CC, Macedonia.</addr-line>
      </aff>
      <author-notes>
        <corresp>Raul Isea, Fundación Instituto de, Estudios, Avanzados, IDEA, Hoyo, de la, Puerta, Baruta, Venezuela, Email: <email>raul.isea@gmail.com</email></corresp>
        <fn fn-type="conflict" id="idm1841413324">
          <p>The authors have declared that no competing interests exist.</p>
        </fn>
      </author-notes>
      <pub-date pub-type="epub" iso-8601-date="2020-07-13">
        <day>13</day>
        <month>07</month>
        <year>2020</year>
      </pub-date>
      <volume>1</volume>
      <issue>3</issue>
      <fpage>16</fpage>
      <lpage>21</lpage>
      <history>
        <date date-type="received">
          <day>23</day>
          <month>06</month>
          <year>2020</year>
        </date>
        <date date-type="accepted">
          <day>07</day>
          <month>07</month>
          <year>2020</year>
        </date>
        <date date-type="online">
          <day>13</day>
          <month>07</month>
          <year>2020</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>© </copyright-statement>
        <copyright-year>2020</copyright-year>
        <copyright-holder>Raul Isea, et al.</copyright-holder>
        <license xlink:href="http://creativecommons.org/licenses/by/4.0/" xlink:type="simple">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="http://openaccesspub.org/ijcv/article/1396">This article is available from http://openaccesspub.org/ijcv/article/1396</self-uri>
      <abstract>
        <p>The present work analyzes the registered cases of Covid-19 throughout the world according the data       registered at Johns Hopkins University.  We selected 15 countries to analyze their data. In alphabetical order the countries are: Argentina, Australia, Brazil, Chile, China, Colombia, Germany, India, Italy, Mexico, Peru, Portugal, Spain, United States and Venezuela. With this information, three different studies were carried out. First, the data was validated using Benford's Law which is based on forensic techniques that allow us to guarantee the integrity of the information. Later, we calculated the value of the basic reproduction number (R<sub>0</sub>), <italic>ie</italic>., the number of secondary host infections caused by one primary host infection that helps us to determine if a country has an outbreak of Covid-19. Finally, we show that the best representation for the change in the number of cases in the time is to              calculate the mantissa value, <italic>ie</italic><italic>.</italic>, the floating number obtained from the logarithm of the data.</p>
      </abstract>
      <kwd-group>
        <kwd>Covid-19</kwd>
        <kwd>R0</kwd>
        <kwd>Reproduction number</kwd>
        <kwd>Benfords Law</kwd>
        <kwd>Mantissa</kwd>
        <kwd>Countries</kwd>
      </kwd-group>
      <counts>
        <fig-count count="1"/>
        <table-count count="2"/>
        <page-count count="6"/>
      </counts>
    </article-meta>
  </front>
  <body>
    <sec id="idm1842851564" sec-type="intro">
      <title>Introduction</title>
      <p>The World Health Organization (WHO) decreed on March 11, 2020 that a new pandemic caused by a new virus first detected in the Wuhan market in China the was caused by a new coronavirus (Covid-19), which was named according to the International Committee of Taxonomy of Virus as Severe Acute Respiratory Syndrome (SARS-CoV-2).</p>
      <p>Until June 3, more than six million cases have been registered throughout the world that is distributed in more than 190 countries and causing more than 380,000 recorded deaths according to the records John Hopkins University records. As a result of all this data, it has been possible to determine, for example, the credibility of the information according to a recent paper published by Isea <xref ref-type="bibr" rid="ridm1843359108">1</xref> where he analyzed 23 countries using the Benford Law. It is interesting to comment that approximately a third of the countries do not satisfy this validation procedure criterion. It is necessary to wait until the end of the epidemic in order to confirm these results <xref ref-type="bibr" rid="ridm1843359108">1</xref>.</p>
      <p>On the other hand, a large number of mathematical models have appeared in the scientific literature that could explain the transmission dynamics of the Covid-19 virus but they depend on a large number of variables which must be continuously adjusted according to the new data <xref ref-type="bibr" rid="ridm1843430092">2</xref><xref ref-type="bibr" rid="ridm1843441900">3</xref><xref ref-type="bibr" rid="ridm1843219492">4</xref><xref ref-type="bibr" rid="ridm1843216540">5</xref><xref ref-type="bibr" rid="ridm1843219852">6</xref>. Therefore, it is necessary to use another type of methodology that allows us to know in real time if a certain country has an epidemic outbreak. To do that, it is necessary to calculate the Basic Reproduction Number (R<sub>0</sub>) that mean the number of new infections that can be generated from one infected person. If the value of R<sub>0</sub>&gt; 1 implies that this country has an epidemic and a value of  R<sub>0</sub>&lt;1  implies that the country has overcome the crisis due to this disease. </p>
      <p>Finally, it is necessary to makea new graphic to see the changes of Covid-19’s infection in each country. To do that, we calculate the mantissa values of the register of cases according to details provided in the following section Therefore, the goal of this paper is to determine: (1) the veracity of the data based on Benford’s Law in the following countries in alphabetical order: Argentina, Australia, Brazil, Chile, China, Colombia, Germany, India, Italy, Mexico, Peru, Portugal, Spain, United States and Venezuela. (2) Calculate the value of R<sub>0</sub> to determine whether an epidemic outbreak is occurring in a country, and (3)Present the values of the mantissa values for the various countries, <italic>ie</italic><italic>.</italic>, China, Italy, Portugal, Spain, United States, Venezuela and World.</p>
    </sec>
    <sec id="idm1842849476" sec-type="methods">
      <title>Methodology</title>
      <p>On June 3, 2020, all cases of Covid-19 infections were obtained from the Johns Hopkins University database in the listed countries. Subsequently, the validity of the data was determined using two digital data analysis techniques based on Benford's Law, according to the procedure recently published by               Isea <xref ref-type="bibr" rid="ridm1843359108">1</xref> which specifies a new critical parameter based on the p-value, which said that is p-value must be greater than 0.05, then the information has received no  manipulation or alteration.</p>
      <p>The next step was to determine the value of the Basic Reproduction Number (R<sub>0</sub>) according to the works published by Isea and Lonngren <xref ref-type="bibr" rid="ridm1843206204">7</xref><xref ref-type="bibr" rid="ridm1843211244">8</xref> which is based on the methodology developed by Wallinga and Lipsitch <xref ref-type="bibr" rid="ridm1843193628">9</xref>. It is necessary to calculate a function called the generation time (mGT) which is the lag time between infection in a primary case and a secondary case. This function before forwards n can only be logarithmic, gamma and weibull, and these definitions are explained in <xref ref-type="bibr" rid="ridm1843192188">10</xref>. </p>
      <p>Finally, the mantissa value is obtained according to the following expression:</p>
      <fig id="idm1841295028">
        <graphic xlink:href="images/image1.png" mime-subtype="png"/>
      </fig>
      <p>where log<sub>10</sub> is the logarithm in base 10 of each cases obtained up to Jun 3, 2020, and “Int” is the whole part of this number. </p>
    </sec>
    <sec id="idm1842834604" sec-type="results">
      <title>Results and Discussions</title>
      <p>(<xref ref-type="table" rid="idm1841272300">Table 1</xref>) shows the results obtained after validating the results using Benford's Law. Remember that the values of χ<sup>2</sup> and L<sup>2</sup> should be close to zero in order to guarantee the integrity of the data and the calculated values of the p-value must be greater than 0.05. From the results shown in <xref ref-type="table" rid="idm1841272300">Table 1</xref>, Australia and China are the countries that best satisfy Benford's Law and therefore, these two countries appear to not manipulate the provided information. Brazil, Colombia, India, Peru, Portugal and Venezuela satisfy two of the tests proposed in this paper and therefore do not alter the data. It is interesting to note that Colombia passes both tests but the value of χ<sup>2</sup> is higher than the other countries.</p>
      <table-wrap id="idm1841272300">
        <label>Table 1.</label>
        <caption>
          <title> Number of Covid-19 case records in 15 countries that have been analyzed in this paper. The others parameters indicated in this table has been explained in the reference 1.</title>
        </caption>
        <table rules="all" frame="box">
          <tbody>
            <tr>
              <td>
                <bold>Country</bold>
              </td>
              <td>
                <bold>χ</bold>
                <sup>2</sup>
              </td>
              <td>
                <bold>p-</bold>
                <bold>value</bold>
                <bold> (χ</bold>
                <sup>2</sup>
                <bold>)</bold>
              </td>
              <td>
                <bold>p-</bold>
                <bold>value</bold>
                <bold> (</bold>
                <bold>arc</bold>
                <bold>mantissa</bold>
                <bold>)</bold>
              </td>
              <td>
                <bold>L</bold>
                <sup>2</sup>
              </td>
            </tr>
            <tr>
              <td>China</td>
              <td>2,3991</td>
              <td>0,9663</td>
              <td>0,4131</td>
              <td>0,0063</td>
            </tr>
            <tr>
              <td>Australia</td>
              <td>6,2668</td>
              <td>0,6174</td>
              <td>0,0669</td>
              <td>0,0289</td>
            </tr>
            <tr>
              <td>Venezuela</td>
              <td>8,5768</td>
              <td>0,3792</td>
              <td>0,4845</td>
              <td>0,0110</td>
            </tr>
            <tr>
              <td>Colombia</td>
              <td>13,2410</td>
              <td>0,1038</td>
              <td>0,1052</td>
              <td>0,0265</td>
            </tr>
            <tr>
              <td>Brasil</td>
              <td>7,2605</td>
              <td>0,5088</td>
              <td>0,1637</td>
              <td>0,0203</td>
            </tr>
            <tr>
              <td>Peru</td>
              <td>10,1920</td>
              <td>0,2518</td>
              <td>0,0810</td>
              <td>0,0292</td>
            </tr>
            <tr>
              <td>Chile</td>
              <td>36,2620</td>
              <td>10-5</td>
              <td>0,0015</td>
              <td>0,0711</td>
            </tr>
            <tr>
              <td>Mexico</td>
              <td>13,7910</td>
              <td>0,0874</td>
              <td>0,0304</td>
              <td>0,0397</td>
            </tr>
            <tr>
              <td>USA</td>
              <td>67,1250</td>
              <td>10-4</td>
              <td>10-10</td>
              <td>0,1976</td>
            </tr>
            <tr>
              <td>Spain</td>
              <td>14,5880</td>
              <td>0,0677</td>
              <td>0,0109</td>
              <td>0,0481</td>
            </tr>
            <tr>
              <td>Portugal</td>
              <td>6,6784</td>
              <td>0,5717</td>
              <td>0,3982</td>
              <td>0,0101</td>
            </tr>
            <tr>
              <td>Italy</td>
              <td>18,7460</td>
              <td>0,0163</td>
              <td>0,0006</td>
              <td>0,0717</td>
            </tr>
            <tr>
              <td>Germany</td>
              <td>11,9940</td>
              <td>0,1515</td>
              <td>0,0334</td>
              <td>0,0347</td>
            </tr>
            <tr>
              <td>India</td>
              <td>10,2410</td>
              <td>0,2485</td>
              <td>0,1532</td>
              <td>0,0204</td>
            </tr>
            <tr>
              <td>Argentina</td>
              <td>21,9220</td>
              <td>0,0051</td>
              <td>0,0002</td>
              <td>0,1017</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <p>On the other hand, Germany, Mexico and Spain meet one of the two tests so these countries do not appear to have manipulated their data either. However<bold>, </bold>Argentina, Chile, Italy and the United States appear to not pass these tests and therefore, there is no guarantee of the validity of the information. However, it is necessary to wait until the end of the pandemic to confirm these preliminary results.</p>
      <p>The next step is to calculate the value of R<sub>0</sub>, it means, the number of new infections that can be generated from one infected person, obtained with the methodology proposed by Isea and Lonngren <xref ref-type="bibr" rid="ridm1843206204">7</xref><xref ref-type="bibr" rid="ridm1843211244">8</xref>, where values ​​greater than 1 indicate that this country is undergoing an epidemic. These results using these criteria are shown in <xref ref-type="table" rid="idm1841196724">Table 2</xref>. Australia and China are the countries with the lowest R<sub>0</sub> value. Therefore, there does not appear to be an epidemic outbreak in these two countries while Germany, Italy and Spain have values just below 1 which theoretically implies that there is no emergency for enduring this disease, but it is necessary checking these results to known when these countries can generated an outbreaks. The remaining countries are presently undergoing Covid-19 epidemics (R<sub>0</sub>&gt; 1). </p>
      <table-wrap id="idm1841196724">
        <label>Table 2.</label>
        <caption>
          <title> Calculated values ​​of R0 according to of number of dates, and the rest of parameters are explained in the reference 10.</title>
        </caption>
        <table rules="all" frame="box">
          <tbody>
            <tr>
              <th>
                <bold>Country</bold>
              </th>
              <td>
                <bold>No dates</bold>
              </td>
              <td>
                <bold>Function</bold>
              </td>
              <td>
                <bold>Median</bold>
              </td>
              <td>
                <bold>SD</bold>
              </td>
              <td>
                <bold>R</bold>
                <sub>
                  <bold>0</bold>
                </sub>
              </td>
            </tr>
            <tr>
              <td>Chin</td>
              <td>156</td>
              <td>Lognormal</td>
              <td>0,1946</td>
              <td>5,2571</td>
              <td>0,9365±0,1666</td>
            </tr>
            <tr>
              <td>Australia</td>
              <td>97</td>
              <td>Lognormal</td>
              <td>0,1237</td>
              <td>0,3108</td>
              <td>0,9675±0,0739</td>
            </tr>
            <tr>
              <td>Venezuela</td>
              <td>81</td>
              <td>Weibull</td>
              <td>0,2196</td>
              <td>0,2750</td>
              <td>1,0829±0,1276</td>
            </tr>
            <tr>
              <td>Colombia</td>
              <td>85</td>
              <td>Gamma</td>
              <td>0,2420</td>
              <td>0,2711</td>
              <td>1,0713±0,0792</td>
            </tr>
            <tr>
              <td>Brasil</td>
              <td>91</td>
              <td>Gamma</td>
              <td>0,1944</td>
              <td>0,2821</td>
              <td>1,0888±0,0994</td>
            </tr>
            <tr>
              <td>Peru</td>
              <td>87</td>
              <td>Gamma</td>
              <td>0,2308</td>
              <td>0,3322</td>
              <td>1,0778±0,0864</td>
            </tr>
            <tr>
              <td>Chile</td>
              <td>91</td>
              <td>Gamma</td>
              <td>0,2183</td>
              <td>0,3024</td>
              <td>1,0882±0,0905</td>
            </tr>
            <tr>
              <td>Mexico</td>
              <td>88</td>
              <td>Gamma</td>
              <td>0,2842</td>
              <td>0,3800</td>
              <td>1,0780±0,0758</td>
            </tr>
            <tr>
              <td>USA</td>
              <td>104</td>
              <td>Gamma</td>
              <td>0,3774</td>
              <td>0,5184</td>
              <td>1,0295±0,0406</td>
            </tr>
            <tr>
              <td>Spain</td>
              <td>92</td>
              <td>Gamma</td>
              <td>0,2706</td>
              <td>0,3224</td>
              <td>0,9902±0,0455</td>
            </tr>
            <tr>
              <td>Portugal</td>
              <td>92</td>
              <td>Weilbull</td>
              <td>0,2414</td>
              <td>0,2282</td>
              <td>1,0012±0,0483</td>
            </tr>
            <tr>
              <td>Italy</td>
              <td>95</td>
              <td>Weibull</td>
              <td>0,3448</td>
              <td>0,3087</td>
              <td>0,9897±0,0341</td>
            </tr>
            <tr>
              <td>Germany</td>
              <td>98</td>
              <td>Gamma</td>
              <td>0,2977</td>
              <td>0,3416</td>
              <td>0,9895±0,0402</td>
            </tr>
            <tr>
              <td>India</td>
              <td>93</td>
              <td>Gamma</td>
              <td>0,2533</td>
              <td>0,3840</td>
              <td>1,0877±0,0838</td>
            </tr>
            <tr>
              <td>Argentina</td>
              <td>89</td>
              <td>Gamma</td>
              <td>0,2612</td>
              <td>0,2963</td>
              <td>1,0692±0,0725</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <p>Finally, in the <xref ref-type="fig" rid="idm1841089580">Figure 1</xref> shows the results of  the mantissa values in the following countries: China, Italy, Portugal, United States, Venezuela and World. When the country does not present an outbreak, the mantissa values are constant in time (see China results). However, the results obtained in the United States and Venezuela show that they have not reached the maximum of cases of Covid-19, while Italy is almost free of this pandemic. Finally, the results obtained in the World shows that has not reached the equilibrium during this time. These results are according to the R<sub>o</sub>’s values obtained in the previous step.</p>
      <fig id="idm1841089580">
        <label>Figure 1.</label>
        <caption>
          <title> The results of the mantissa values in the following countries: China, Italy, Portugal, United States, Venezuela and World.</title>
        </caption>
        <graphic xlink:href="images/image2.jpg" mime-subtype="jpg"/>
      </fig>
    </sec>
    <sec id="idm1842746548" sec-type="conclusions">
      <title>Conclusions</title>
      <p>This paper analyzes the data recorded for      Covid-19 throughout the world. With this information, it is possible to verify which countries are currently experiencing a new coronavirus (Covid-19) epidemic according to the R<sub>0</sub> value, and also the known countries which countries do not manipulate the data. Finally, it was possible to know if a country presents an outbreak according to the mantissa result, but it is necessary to do more investigations in the future.</p>
    </sec>
  </body>
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